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[Combination of Immunotherapy and Hyperthermia]. | LitMetric
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[Combination of Immunotherapy and Hyperthermia].

Yui Kubota Tsutomu Takeda Takashi Takeda Takehiro Noda Nobuaki Hattori Kana Nakamura Tomoyo Yasuda Takeo Hasegawa Yuhki Yokoyama Hirofumi Yamamoto Hiroko Takeda

Gan To Kagaku Ryoho

Dept. of Molecular Pathology, Division of Health Science, Graduate School of Medicine, Osaka University.

Published: October 2019

We treated 123cancer patients with a combination of immune checkpoint inhibitor and dendritic cell therapy between June 2015 and April 2019. The effective rate of cases administered for B3times was 51.5%. Hyperthermia was found to enhance the effects of radiotherapy, chemotherapy, and immunotherapy. In addition, hyperthermia enhanced the effects of combined immunotherapy. In clinical cases and animal models, immunohistochemical staining showed that the expression of PD-L1 and MHC classⅠ and invasion of CD8 cells were increased after hyperthermia.

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