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[Sacituzumab govitecan in the treatment of triple-negative metastatic breast cancer.].
Recenti Prog Med
December 2024
UO Clinica di Oncologia medica, Irccs Ospedale Policlinico San Martino, Genova - Dipartimento di Medicina interna e specialità mediche (DiMI), Scuola di Medicina e Chirurgia, Università di Genova.
The clinical management of triple-negative breast cancer has been very difficult for a long time, being classical chemotherapy the only possible therapeutic approach given the absence of specific targets. However, the therapeutic armamentarium has recently been expanded thanks to the introduction of new molecules, in particular immunotherapy and antibody-drug conjugates (ADCs), which have made it possible to significantly improve the prognosis of this patient population both in the early and advanced settings. Since 2022, the ADC sacituzumab govitecan has been approved by the Italian Medicines Agency (Aifa) for the treatment of advanced/metastatic triple-negative breast cancer pretreated with at least two lines of systemic therapy, of which at least one for metastatic disease.
View Article and Find Full Text PDFPrecision models in hepatocellular carcinoma.
Nat Rev Gastroenterol Hepatol
December 2024
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hepatocellular carcinoma (HCC) represents a global health challenge, and ranks among one of the most prevalent and deadliest cancers worldwide. Therapeutic advances have expanded the treatment armamentarium for patients with advanced HCC, but obstacles remain. Precision oncology, which aims to match specific therapies to patients who have tumours with particular features, holds great promise.
View Article and Find Full Text PDFCrimean-Congo haemorrhagic fever (CCHF): present and future therapeutic armamentarium.
Infez Med
December 2024
Department of Systems Medicine, Tor Vergata University, Rome, Italy.
Crimean-Congo haemorrhagic fever (CCHF) is an emerging severe tick-borne illness. The expanding habitat of ticks, coupled with migratory birds harbouring CCHF-infected ticks, contributes to an increasing number of potential hosts. The seroprevalence of anti-CCHF virus antibodies in livestock is approximately one-quarter, with a noticeable upward trend in recent years.
View Article and Find Full Text PDFAustralian outcomes from heart transplantation in the machine perfusion era.
Ann Cardiothorac Surg
November 2024
Heart Transplant Unit, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.
Background: In the current era of heart transplantation, machine perfusion strategies are emerging as potential additions to the armamentarium of a transplant unit. Donation after circulatory death (DCD) donor hearts assessed through normothermic machine perfusion (NMP) has helped expand the donor pool. Hypothermic machine perfusion (HMP) is emerging as an alternative strategy to traditional static cold storage (SCS) when a prolonged ischemic time is anticipated in brain dead (BD) donors, this is important in Australia where long distant procurement is vital.
View Article and Find Full Text PDFNavigating the Complexities of Radiation Injuries: Therapeutic Principles and Reconstructive Strategies.
J Pers Med
November 2024
Department 11, Discipline Plastic and Reconstructive Surgery, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania.
Radiation injuries, particularly those resulting from therapeutic or accidental exposure, present complex challenges for medical management. These injuries can manifest localized skin damage or extend to deeper tissues, presenting as various clinical entities that require treatment strategies, ranging from conservative management to complex surgical interventions. Radiation treatment constitutes a fundamental component of neoplastic management, with nearly two out of three oncological instances undergoing it as an element of their therapeutic strategy.
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