Natural history and imaging in men with high genetic risk for developing prostate cancer.

Prostate cancer is the most common malignancy and the second leading cause of cancer related deaths in the United States. Established risk factors for prostate cancer incidence include older age, African-American race, and positive family history. Prostate cancer has substantial inherited predisposition and certain genetic variants are associated with increased risk of disease. Screening and imaging should target high-risk populations based on their genetic predisposition.