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Analysis of the distribution of mechanical load on the plate and lateral hinge of a valgus-producing open wedge high tibial osteotomy during weight-bearing by simulating consolidation. Finite element study.
Orthop Traumatol Surg Res
December 2024
Laboratoire ICube, Université de Strasbourg - CNRS, 4 rue de la Manufacture des Tabacs, 67000 Strasbourg, France; Service de Chirurgie Orthopédique et de Traumatologie, Hôpital de Hautepierre II, 1 Avenue Molière, 67098 Strasbourg Cedex, France. Electronic address:
Introduction: High tibial osteotomy (HTO) is indicated for managing isolated medial knee osteoarthritis in a young patient with a metaphyseal deformity of the proximal tibia. In a medial open-wedge HTO, maintaining the integrity of the hinge is crucial for consolidation and preservation of the correction. Based on a validated model and preliminary results, the objective of this work was to measure and monitor the distribution of mechanical load on a locking fixation plate and the lateral hinge of an HTO using a finite element (FE) model during different phases of consolidation evolution, simulating single leg weightbearing.
View Article and Find Full Text PDFThe analysis and reporting of multiple outcomes in mental health trials: a methodological systematic review.
BMC Med Res Methodol
December 2024
Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Background: The choice of a single primary outcome in randomised trials can be difficult, especially in mental health where interventions may be complex and target several outcomes simultaneously. We carried out a systematic review to assess the quality of the analysis and reporting of multiple outcomes in mental health RCTs, comparing approaches with current CONSORT and other regulatory guidance.
Methods: The review included all late-stage mental health trials published between 1st January 2019 to 31st December 2020 in 9 leading medical and mental health journals.
Coagulopathy in acute liver failure.
Best Pract Res Clin Gastroenterol
December 2024
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
Acute liver failure (ALF) is a rare but rapidly progressing syndrome, marked by severe liver dysfunction and altered mental status. While definitions of ALF vary across different guidelines, with timelines ranging from 4 to 26 weeks between jaundice onset and encephalopathy, the key defining features remain encephalopathy and coagulopathy. Elevated coagulation markers, particularly prothrombin time and international normalized ratio, have traditionally been associated with bleeding risks.
View Article and Find Full Text PDFPerformance of ChatGPT in French language analysis of multimodal retinal cases.
J Fr Ophtalmol
December 2024
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology, St. Michael's Hospital/Unity Health Toronto, Toronto, Ontario, Canada. Electronic address:
Purpose: Prior literature has suggested a reduced performance of large language models (LLMs) in non-English analyses, including Arabic and French. However, there are no current studies testing the multimodal performance of ChatGPT in French ophthalmology cases, and comparing this to the results observed in the English literature. We compared the performance of ChatGPT-4 in French and English on open-ended prompts using multimodal input data from retinal cases.
View Article and Find Full Text PDFInterhospital variations in diagnostic work-up following recall at biennial screening mammography-a population-based study.
Eur Radiol
December 2024
Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands.
Objectives: Quality control in breast cancer screening programmes has been subject of several studies. However, less is known about the clinical diagnostic work-up in recalled women with a suspicious finding at screening mammography. The current study focuses on interhospital differences in diagnostic work-up strategies.
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