AI Article Synopsis
- ALK-tRCC is a recently identified rare subtype of renal cell carcinoma that has been added to the World Health Organization's classification as an emerging category in 2016.* -
- A case study presented a 58-year-old Chinese man with a kidney tumor characterized by large cells, distinct vacuoles, and significant nuclear enlargement; the tumor showed positive markers indicating epithelial features.* -
- Diagnosing ALK-tRCC can be challenging due to its diverse histological characteristics, and it's recommended to conduct screening for ALK expression as it may allow patients to benefit from targeted ALK inhibitor therapies.*
Article Abstract
Background: Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years. It was recognized as a group of emerging /provisional RCC in the latest World Health Organization's classification (2016).
Case Presentation: A new Chinese case of ALK-tRCC was reported. The patient was a 58-year-old man with a tumor in kidney. The tumor was composed of sheets of large cells with abundant eosinophilic cytoplasm and indistinct cell borders but conspicuous intracytoplasmic vacuoles. The nuclei were enlarged with a nucleolar of grade 4. Immunohistochemically, tumor cells were diffusely positive for PAX8, keratin (AE1/AE3), epithelial membrane antigen (EMA) and CK7. Fluorescent in situ hybridization (FISH) showed a rearrangement of ALK in tumor cells.
Conclusion: ALK-tRCC is a rare subtype of adult RCC. Its diagnosis is very difficult because the histological spectrum is very wide. We suggested that RCCs should be screened for ALK expression by immunohistochemistry (IHC) for the patient might benefit from ALK inhibitors therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798478 | PMC |
| http://dx.doi.org/10.1186/s13000-019-0879-0 | DOI Listing |
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