[Residual hyperten sion and myocardial hypertrophy in patients operated on for acromegalia].

То study a role of hemodynamic and humoral factors in the development of arterial hypertension and myocardial hypertrophy, 20 and 21 patients with acromegalia were examined before and in the late periods after radical surgical treatment, respectively, for growth hormone-producing pituitary adenoma. The patients underwent blood pressure and central hemodynamic measurements, echocardiography, and some hormones testing at rest and after antiorthostatic tests and exercises. In patients with acromegalia, arterial hypertension occurring in the late postoperative periods was ascertained to be associated with higher vascular resistance, exhausted depressor prostaglandin system, impaired aldosterone and Cortisol reactivity, and insulin hypertension. Concentric left ventricular hypertrophy with diastolic dysfunction persisted in most patients long after surgery being maintained by hypertension and hyperin-sulinemia. Exercise tests indicated the impaired endocrine system responsiveness and diminished cardiac performance due to cardiosclerosis.