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Understanding the effects of Bothrops erythromelas and Bothrops leucurus venoms on human blood coagulation.
Toxicon
January 2025
Laboratório de Herpetologia, Instituto Butantan, São Paulo, Brasil; Programa de Pós-Graduação Interunidades em Biotecnologia, São Paulo, Brasil; Laboratório de Fisiopatologia, Instituto Butantan, São Paulo, Brasil. Electronic address:
Coagulation disorders are a primary symptom of envenomation caused by snakes belonging to the genus Bothrops. In the Northeast region of Brazil, the species Bothrops erythromelas and Bothrops leucurus are the main responsible for snakebite accidents. Due to the specific action of Bothrops venoms on several components of the coagulation cascade, the objective of this work was to characterize the coagulotoxic profile of B.
View Article and Find Full Text PDFEvaluating ADHD medication trial representativeness: a Swedish population-based study comparing hypothetically trial-eligible and trial-ineligible individuals.
Lancet Psychiatry
January 2025
Developmental Evidence synthesis, Prediction, Implementation lab, Centre for Innovation in Mental Health, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK; Hampshire and Isle of Wight NHS Foundation Trust, Southampton, UK; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, NY, USA; DiMePRe-J-Department of Precision and Regenerative Medicine-Jonic Area, University of Bari Aldo Moro, Bari, Italy.
Background: Randomised controlled trials (RCTs) evaluating ADHD medications often use strict eligibility criteria, potentially limiting generalisability to patients in real-world clinical settings. We aimed to identify the proportion of individuals with ADHD who would be ineligible for medication RCTs and evaluate differences in treatment patterns and clinical and functional outcomes between RCT-eligible and RCT-ineligible individuals.
Methods: We used multiple Swedish national registries to identify individuals with ADHD, aged at least 4 years at the age of diagnosis, initiating pharmacological treatment between Jan 1, 2007, and Dec 31, 2019, with follow-up up to Dec 31, 2020.
Fatal Waterhouse-Friderichsen Syndrome caused by Streptococcus pneumoniae in a vaccinated adult with traumatic splenectomy: A case report.
Leg Med (Tokyo)
January 2025
University of Modena and Reggio Emilia, Italy. Electronic address:
Waterhouse-Friderichsen Syndrome (WFS) is a rare but life-threatening condition characterized by massive adrenal hemorrhage. WFS represents one of the features of the Overwhelming Post-Splenectomy Infection, which occurs any time after spleen removal and is recognized as the most serious complication in asplenic patients. We report a fatal case of WFS resulting from Streptococcus pneumoniae infection in a vaccinated and splenectomized patient.
View Article and Find Full Text PDFDriving under the influence of drugs - The failed quest of finding medical signs indicative to driving impairment.
Leg Med (Tokyo)
January 2025
Department of Forensic Medicine, Medical School, University of Pécs, Pécs, Hungary. Electronic address:
Motor vehicle accidents (MVA) are the leading cause of death in childhood and young adult age. One of the most important factors behind MVA is driving under the influence of alcohol (DUIA) and drugs (DUID). The importance of DUID is rising together with the increasing drug abuse.
View Article and Find Full Text PDFExploring the Mechanism for Increased Risk in Freeway Tunnel Approach Zones: A Perspective on Temporal-spatial Evolution of Driving Predictions, Tasks, and Behaviors.
Accid Anal Prev
January 2025
School of Transportation and Logistics Engineering, Wuhan University of Technology, Wuhan 430063, PR China.
Freeway tunnel approach zones, situated outside the tunnel, do not undergo the same sudden changes in luminous environment and visual references that entrance zones experience. Despite this, accident data indicates that approach zones present similar safety risks to entrance zones, both of which are significantly higher than other tunnel sections. The reasons for the heightened risks in approach zones remain unclear in existing research.
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