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Drug orientations within statin-loaded lipoprotein nanoparticles by F solid-state NMR. | LitMetric
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Drug orientations within statin-loaded lipoprotein nanoparticles by F solid-state NMR.

Sophie Lau Naomi Stanhope John Griffin Eleri Hughes David A Middleton

Chem Commun (Camb)

Department of Chemistry, Lancaster University, Lancaster LA1 4YB, UK.

Published: October 2019

NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.

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 Source
http://dx.doi.org/10.1039/c9cc05344aDOI Listing

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