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A comprehensive review of topical hemostatic agents: The good, the bad, and the novel. | LitMetric

A comprehensive review of topical hemostatic agents: The good, the bad, and the novel.

J Trauma Acute Care Surg

From the Division of Surgical Critical Care, Trauma, and Acute Care Surgery (A.J.T.), University of Arizona-Phoenix, Phoenix, Arizona; Department of General Surgery (A.u.R.G.), SAIMS Hospital, Indore, MP, India; Gel-E, Inc. (M.D.), Phoenix, Arizona; Department of Surgery (S.B.J.), University of Arizona-Phoenix, Phoenix, Arizona; Division of Trauma, Burns, Acute and Critical Care (P.S.B., R.J.W., M.N.), New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, New York; Division of Trauma, Emergency Surgery and Surgical Critical Care (D.K.), Massachusetts General Hospital, Boston, MA; R. Adams Cowley Shock Trauma Center (T.M.S.), University of Maryland Medical Center, Baltimore, Maryland; and Department of Surgery (L.D.B.), Eastern Virginia Medical School, Norfolk, Virginia.

Published: January 2020

AI Article Synopsis

  • Uncontrolled bleeding is the main cause of death in trauma patients, especially before they reach the hospital.
  • Effective and rapid hemorrhage control is crucial for healthcare providers working in prehospital settings.
  • The article reviews various hemostatic products developed over the years and aims to provide guidance on their use while pointing out future developments in the field.

Article Abstract

Uncontrolled exsanguination remains the leading cause of death for trauma patients, many of whom die in the pre-hospital setting. Without expedient intervention, trauma-associated hemorrhage induces a host of systemic responses and acute coagulopathy of trauma. For this reason, health care providers and prehospital personal face the challenge of swift and effective hemorrhage control. The utilization of adjuncts to facilitate hemostasis was first recorded in 1886. Commercially available products haves since expanded to include topical hemostats, surgical sealants, and adhesives. The ideal product balances efficacy, with safety practicality and cost-effectiveness. This review of hemostasis provides a guide for successful implementation and simultaneously highlights future opportunities.

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Source
http://dx.doi.org/10.1097/TA.0000000000002508DOI Listing

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