AI Article Synopsis
- CRISPR-Cas systems are powerful tools for genome manipulation, particularly the Class 2 type II system, which has been widely studied across various organisms including mammalian cells, plants, fungi, and bacteria.
- * Pathogenic fungi are significant contributors to human diseases, making genetic manipulation crucial for developing new therapies and antifungal treatments.
- * The review focuses on advancements in using CRISPR systems for human pathogenic fungi, highlighting improvements in research utility and exploring potential future applications.*
Article Abstract
Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Cas systems have emerged as a powerful tool for genome manipulation. Class 2 type II CRISPR/ is so far the most studied system and has been implemented in many biological systems such as mammalian cells, plants, fungi and bacteria. Fungi are important causes of human diseases worldwide. Genetic manipulation of pathogenic fungi is critical to develop new therapeutic approaches and novel antifungals. We will review here the progress done with CRISPR/ systems in human pathogenic fungi, with emphasis in and the main modifications that have improved their usefulness in biological research. We finally discuss possible future outcomes and applications to the developed in a near future.
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| http://dx.doi.org/10.2217/fmb-2019-0183 | DOI Listing |
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