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Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial.
Lancet Haematol
June 2024
Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH, USA; Global Health Center, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Background: Realizing Effectiveness Across Continents with Hydroxyurea (REACH) is an open-label non-randomised trial of hydroxyurea (hydroxycarbamide) in children with sickle cell anaemia in sub-Saharan Africa. The short-term results of REACH on safety, feasibility, and effectiveness of hydroxyurea were published previously. In this paper we report results from extended hydroxyurea treatment in the REACH cohort up to 8 years.
View Article and Find Full Text PDFParvovirus B19 DNA detectable in hearts of patients with dilated cardiomyopathy, but absent or inactive in blood.
ESC Heart Fail
August 2021
Department of Blood-borne Infections, Donor Medicine Research, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.
Aims: Parvovirus B19 (B19V) is often assumed to be a cause of dilated cardiomyopathy (DCM), based on the quantification of B19V DNA in endomyocardial biopsies (EMB). Whether the presence of B19V DNA correlates with active infection is still debated. Application of the enzyme endonuclease to blood samples results in degradation of B19V DNA remnants but leaves viral particles intact, which enables differentiation between active and past infection.
View Article and Find Full Text PDFMolecular evidence of parvovirus B19 in the cutaneous polyarteritis nodosa tissue from a patient with parvovirus-associated hemophagocytic syndrome: Case report.
Medicine (Baltimore)
September 2020
Departments of Internal Medicine, Kyungpook National University, School of Medicine, Daegu, Republic of Korea.
Rationale: Parvovirus B19 has been linked to polyarteritis nodosa (PAN), but there is some controversy about its pathogenesis regarding whether it is triggered by the immune complex or by the activated immune cells that phagocytose viruses.
Patient Concerns: A 38-year-old woman was admitted with fever and bicytopenia. She also complained of a painful palpable nodule in the left forearm.
A Human Parvovirus-Associated Arthritis: Arthrocentesis may Resolve Coxalgia.
Indian J Pediatr
June 2020
Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.
A detailed analysis of synonymous codon usage in human bocavirus.
Arch Virol
February 2019
Department of Biomedical Science, College of Clinical Pharmacy, King Faisal University, P.O Box 400, Al-Ahsa, 31982, Kingdom of Saudi Arabia.
Human bocavirus (HBoV) is a recently discovered parvovirus associated with respiratory and gastroenteric infections in children. To date, four distinct subtypes have been identified worldwide. HBoV1 is the most frequently detected bocavirus in clinical samples derived from the respiratory tract.
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