In multinodular lesions or tumors with mixed benign and malignant components, malignant elements may be undetectable using fine-needle aspiration biopsy/cytology in preoperative pathological diagnosis of some cases, because of sampling error.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787811PMC
http://dx.doi.org/10.1002/ccr3.2417DOI Listing

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