A TCR-Dependent Tissue Repair Potential of MAIT Cells.

Trends Immunol

INSERM U932, PSL University, Institut Curie, Paris 75005, France; Laboratoire d'Immunologie Clinique, Institut Curie, Paris 75005, France; Centre d'Investigation Clinique en Biothérapie Gustave-Roussy Institut Curie (CIC-BT1428), Paris 75005, France. Electronic address:

Published: November 2019

Three studies published in Cell Reports (Hinks et al., Lamichhane et al., and Leng et al.) describe the transcriptome of human and mouse mucosal-associated invariant T (MAIT) cells after cognate and noncognate stimulation. The results confirm the variability of MAIT cell effector functions and provide evidence of a new tissue-repair gene signature expressed upon T cell receptor (TCR) stimulation.

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http://dx.doi.org/10.1016/j.it.2019.09.001DOI Listing

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