AI Article Synopsis
- A rare case of a new reciprocal translocation (t(11;21)(q13;q22)) was reported alongside the Philadelphia chromosome in a patient with chronic myelogenous leukemia (CML).
- This translocation and a missing Y chromosome were observed during both the progression to a blastic crisis and the return to the chronic phase of the disease.
- The implications of this genetic abnormality for the patient's condition and treatment are explored.
Article Abstract
Reciprocal translocations, in addition to that of the Ph chromosome, though rare, have been reported in chronic myelogenous leukemia (CML). We describe here a case of Ph-positive CML with a new translocation, t (11;21) (q13;q22), and missing Y, which were present both during transformation to the blastic crisis and in the subsequent reversion to the chronic phase. The possible significance of this abnormality is discussed.
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| http://dx.doi.org/10.1016/0165-4608(88)90216-6 | DOI Listing |
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