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Synthesis and anti-leishmanial activity of TRIS-glycine-β-alanine dipeptidic triazole dendron coated with nonameric mannoside glycocluster. | LitMetric
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Synthesis and anti-leishmanial activity of TRIS-glycine-β-alanine dipeptidic triazole dendron coated with nonameric mannoside glycocluster.

Sushil V Pawar Puspesh K Upadhyay Sachin Burade Navanath Kumbhar Rajendra Patil Dilip D Dhavale

Carbohydr Res

Department of Chemistry, Savitribai Phule Pune University (Formerly University of Pune), Pune, 411 007, India. Electronic address:

Published: November 2019

Tripodal nonameric mannoside glycodendrimer 1 with carbohydrate tethered triazole linked with the TRIS-glycine-β-alanine dipeptidic aromatic centered core was synthesized. Glycodendrimer 1 demonstrated potential in vitro anti-leishmanial activity. The bio-activity data was substantiated with molecular modelling and docking studies of 1 with the three-dimensional protein structure of Leishmanolysin.

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http://dx.doi.org/10.1016/j.carres.2019.107815DOI Listing

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