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Drug Development.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: The ability to monitor cognitive trajectories over the course of trials can provide valuable insights into treatment efficacy. However, existing trial methods are limited in monitoring cognition in real-time and at high frequencies. Gameplay-based assessments hold promise as complementary cognitive tools.
View Article and Find Full Text PDFTransition Boundary from Laminar to Turbulent Flow of Microencapsulated Phase Change Material Slurry-Experimental Results.
Materials (Basel)
December 2024
Department of Mechanical and Power Engineering, Koszalin University of Technology, Raclawicka Street 15-17, 75-620 Koszalin, Poland.
An ice slurry or an emulsion of a phase change material (PCM) is a multiphase working fluid from the so-called Latent Functional Thermal Fluid (LFTF) group. LFTF is a fluid that uses, in addition to specific heat, the specific enthalpy of the phase change of its components to transfer heat. Another fluid type has joined the LFTF group: a slurry of encapsulated phase change material (PCM).
View Article and Find Full Text PDFCharacterization and PCR Application of Family B DNA Polymerases from .
Life (Basel)
November 2024
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
DNA polymerases from the hyperthermophilic Archaea have attracted considerable attention as PCR enzymes due to their high thermal stability and proofreading 3' → 5' exonuclease activity. This study is the first to report data concerning the purification and biochemical characteristics of the Tst DNA polymerase from . Both the wild type Tst(wt) DNA polymerase and its chimeric form containing the P36H substitution-which reduces the enzyme's affinity for the U-containing template and dUTP-and the DNA-binding domain Sso7d from were obtained and analyzed.
View Article and Find Full Text PDFCommunity Awareness and Perceptions of Genitourinary Malformations: A Cross-Sectional Survey Study.
Healthcare (Basel)
December 2024
Departments of Surgery, College of Medicine, King Faisal University, Al Hofuf P.O. Box 400, Saudi Arabia.
Background And Objectives: On a local and national scale, genitourinary malformations (GUMs) are the second most encountered congenital anomaly in children. GUMs are linked to several risk factors, including maternal co-morbidities and insufficient folic acid. They may also be related to maternal health and care during pregnancy.
View Article and Find Full Text PDFImportance of EQA/PT for the detection of genetic variants in comprehensive cancer genome testing.
Sci Rep
January 2025
Genetic Analysis Department, Tsukiji Registered Clinical Laboratory, Riken Genesis Co., Ltd., Tokyo, Japan.
Comprehensive genomic profiling (CGP) is increasingly used as a clinical laboratory test and being applied to cancer treatment; however, standardization and external quality assessments (EQA) have not been fully developed. This study performed cost-effective EQA and proficiency tests (PT) for CGP testing among multiple institutions those belong to the EQA working group of Japan Association for Clinical Laboratory Science (JACLS). This study revealed that preanalytical processes, such as derived nucleic acids (NA) extraction from formalin fixed paraffine embedded (FFPE) samples, are critical.
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