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Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors.
Sci Rep
January 2025
Department of Mathematics and Statistics, College of Science, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
The monkeypox virus (MPXV), which is a member of the Orthopoxvirus genus in the class Poxviridae, is the causative agent of the zoonotic viral infection MPXV. The disease is similar to smallpox, but it is usually less dangerous. This study examines the evolution of the MPXV epidemic in Canada with an emphasis on the effects of control employing actual data.
View Article and Find Full Text PDFArt of TIL immunotherapy: SITC's perspective on demystifying a complex treatment.
J Immunother Cancer
January 2025
Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
In a first for solid cancers, cellular immunotherapy has entered standard of care in the treatment of patients with metastatic melanoma. The infusion of autologous tumor-infiltrating T lymphocytes (TIL) is capable of mediating durable tumor regression and is now Food and Drug Administration-approved for patients with disease refractory to immune checkpoint inhibitors. Since the advent of chimeric antigen receptor (CAR) T cells for patients with hematological malignancies, a growing network of centers capable of delivering effector T cell products to patients has developed.
View Article and Find Full Text PDFCD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist?
Lupus Sci Med
January 2025
Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
CD19-directed chimeric antigen receptor (CAR) T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases. By selectively depleting CD19-positive B-cells, this therapy brings a new approach in resetting immune dysregulation and potentially providing long-term remission for patients with a refractory disease. Recent reports have highlighted its effectiveness in conditions such as SLE, systemic sclerosis and myositis.
View Article and Find Full Text PDFBenefits, challenges, and best practices of collaborative partnerships among health supply chain stakeholders in Rwanda: a cross-sectional study.
BMC Health Serv Res
January 2025
School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, P.O. Box 3286, Kigali, Rwanda.
Background: Strong partnerships, community engagement, and multisectoral collaboration in the health supply chain are synergistic pillars towards achieving universal health coverage. In Rwanda, the health supply chain involves the collaboration of various stakeholders, including distributors, manufacturers, wholesalers, and customers. However, since the eruption and ending of COVID-19, there has not been any study to assess stakeholders' perspectives on the status of the benefits, challenges, and best practices of collaborative partnerships among health supply chain stakeholders in Rwanda.
View Article and Find Full Text PDFVaccination status and hepatitis A immunity in children: insights from a large-scale study in Turkey.
BMC Infect Dis
January 2025
Department of Pediatrics, Ankara Bilkent City Hospital, Bilkent, Ankara, 06800, Turkey.
Background: Hepatitis A remains a public health concern, particularly in areas with suboptimal sanitation. Introduced in Turkey's immunization schedule in 2011, the vaccine has improved immunity; however, gaps persist, especially in older, unvaccinated children. This study examines the seropositivity rates and antibody levels in children across different vaccination statuses and age groups, and to identify gaps in immunity, particularly among children those born before the introduction of the hepatitis A vaccine in Turkey.
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