AI Article Synopsis
- * Researchers analyzed 40 genome sequences of PCV2 from Shandong Province, revealing the coexistence of three genotypes (2a, 2b, 2d), with PCV2d emerging as the dominant type.
- * Analysis of amino acid sequences indicated distinct sites that differentiate the genotypes, suggesting that the rising prevalence of PCV2d might lead to it outcompeting PCV2b as the main strain in the region.
Article Abstract
PCV2 belongs to the genus Circovirus, family Circoviridae, who is recognized as the causative agents of postweaning multisystemic wasting syndrome. Since being found to China in 2000, it has caused serious damage to the pig industry. In this study, we downloaded 40 PCV2 genome-wide sequences uploaded to GenBank from 2013 to 2018 in Shandong Province, including 23 uploaded by our laboratory. Construction of a genome-wide evolution tree using MEGA V5.0 software. Phylogenetic tree analysis indicated that the genotype of PCV2 in Shandong Province was: three genotypes coexisted (2a, 2b, 2d); among them, PCV2d has become the main genotype in the province due to its number and spread range. Amino acid sequence analysis of different genotypes of ORF2 showed that specific amino acid sites exist in different genotypes, with the most significant range of 81-160; different genotypes of PCV2 can be distinguished at the molecular level. This study found that due to the increase in infections of the PCV2d genotype in recent years, it may replace PCV2b as the dominant base in Shandong.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036300 | PMC |
| http://dx.doi.org/10.1002/vms3.196 | DOI Listing |
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