Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00259-019-04542-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Reina Sofia Alzheimer Centre, CIEN Foundation, ISCIII, Madrid, Spain.
Background: About 20-30% of clinically diagnosed AD dementia patients do not meet pathologic criteria for AD and this proportion is even higher in amnestic MCI. Among tau-negative amnestic patients, limbic-predominant age-related TDP-43 encephalopathy (LATE) has been described as a principal diagnostic alternative, especially at advanced age. LATE is characterized by a specific temporo-limbic hypometabolic signature on FDG-PET that may aid in differential diagnosis.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Centre for Brain Research (CBR), Indian Institute of Science, Bengaluru, Karnataka, India.
Background: Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the brain resulting gradual decline in a cognitive function, memory impairment, alterations in behavior, potentially resulting in the inability to engage in a conversation and react to the surroundings. Corpus callosum (CC) is the principal white fabric matter present in the center of the brain that connects the left and right cerebral hemispheres. Neurodegenerative diseases can impact the size and structure of the CC, leading to its atrophy and dysfunction.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Brain age (BA) prediction models have emerged as valuable tools for understanding individual differences in trajectories of brain aging. These models aim to estimate overall brain health by predicting BA based on structural MRI data. To enhance the specificity of existing BA models, we introduce a deep learning-based BA prediction model.
View Article and Find Full Text PDFBackground: Argentina is the second-largest country in Latin America, home to 9% of the world's Latino population. Like the rest of Latin America, it is grappling with the aging of its population and an increase in risk factors. Despite this, there are currently no studies on the incidence of dementia in the national territory.
View Article and Find Full Text PDFBackground: Type-2 diabetes mellitus is associated with both altered white matter microstructural integrity and increased risk of dementia. However, whether there is a link between the white matter changes in older adults with diabetes and their cognitive decline remains unclear. The objective of this study was to examine the association of diabetes-related changes in white-matter microstructural integrity with longitudinally assessed late-life cognitive function.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!