Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789294PMC
http://dx.doi.org/10.21037/sci.2019.08.04DOI Listing

Publication Analysis

Top Keywords

crispr-activation-based screen
4
screen reveals
4
reveals neuronal
4
neuronal fate
4
fate promotion
4
promotion polycomb
4
polycomb repressive
4
repressive complex
4
complex direct
4
direct reprogramming
4

Similar Publications

RNA variant assessment using transactivation and transdifferentiation.

Am J Hum Genet

August 2024

The Robinson Research Institute, University of Adelaide, Adelaide, SA 5005, Australia; School of Biomedicine, University of Adelaide, Adelaide, SA 5005, Australia. Electronic address:

Article Synopsis
  • * A significant challenge arises from "silent" Mendelian genes (SMGs), which show insufficient expression in patient tissues; 36% of these genes are linked to neurological disorders, highlighting the need for improved gene expression techniques.
  • * Researchers developed two methods—CRISPR-based gene activation and fibroblast-to-neuron transdifferentiation—to induce SMG expression, achieving remarkable success and enabling further investigation of variants in genes linked to specific diseases.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!