The use of the treadmill exercise test is envisaged only as a means of chronic surveillance of the arteriopathy. The walking distance measured in this way is a complex factor to analyze due to interference of non-vascular phenomena and the effect of training. Manometric data (distal arterial pressure, normalized by determination of the distal pressure/central pressure quotient expressed as percent) were collected during recuperation. Variability (of the order of 18% after 5 min) was studied and compared with that of manometric data at rest (approximately 10%). Fifty-one unoperated patients with arteriopathy were studied prospectively one year after their first visit, and an attempt made to establish a clinical judgement, as to the course of the disease, on the basis of hemodynamic tests, taking into account their variability. Examination at rest is usually sufficient for a valid clinical judgement to be made. However, certain types of treatment such as transluminal angioplasty produce effects that appear to evaluate it with greater precision by examination of dynamic data. Certain specific cases also reveal enhanced sensitivity of variables recorded in hemodynamic parameters after effort. In these cases both manometric and femoral Doppler signal data should be studied.
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J Hypertens
November 2024
Faculty of Sport Sciences, Universidad Europea de Madrid.
Objectives: The effects of acute physical exercise in patients with resistant hypertension remain largely unexplored compared with hypertensive patients in general. We assessed the short-term effects of acute moderate-intensity (MICE) and high-intensity interval exercise (HIIE) on the clinic (BP) and 24-h ambulatory blood pressure (ABP) of patients with resistant hypertension.
Methods: Using a crossover randomized controlled design, 10 participants (56 ± 7 years) with resistant hypertension performed three experimental sessions: MICE, HIIE, and control.
J Physiol
January 2025
Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Exercise provides health benefits to multiple metabolic tissues through complex biological pathways and interactions between organs. However, investigating these complex mechanisms in humans is still limited, making mouse models extremely useful for exploring exercise-induced changes in whole-body metabolism and health. In this review, we focus on gaining a broader understanding of the metabolic phenotypes and molecular mechanisms induced by exercise in mouse models.
View Article and Find Full Text PDFMonaldi Arch Chest Dis
January 2025
Department of Human Neurosciences, Sapienza University, Rome.
In the last few years, we have seen the gradual spread of a new treadmill training modality, which involves walking not on the flat but downhill, also known as "downhill". This review aims to qualitatively assess the efficacy of downhill treatment on different patient populations and outline treatment routes for future efficacy studies. We searched five different databases: MEDLINE, SCOPUS, Web of Science, PEDro, and LILACS for studies to include.
View Article and Find Full Text PDFMed Sci Sports Exerc
January 2025
School of Physical Education and Sports Science, South China Normal University, Guangzhou, CHINA.
Purpose: This study aimed to investigate the pathological responses of glial cells at different distances from amyloid plaques and the characteristics of oligodendrocyte precursor cells (OPCs) in perivascular clustering. Additionally, it sought to explore the impact of exercise training on AD pathology, specifically focusing on the modulation of glial responses and the effects of OPC perivascular clustering.
Methods: Three-month-old C57BL/6 and APP/PS1 mice were divided into four groups: wild-type sedentary, wild-type exercise, sedentary AD, and exercise AD groups.
Sci Data
January 2025
University of Delaware, Department of Mechanical Engineering, Newark, DE, 19716, USA.
Walking on compliant terrains, like carpets, grass, and soil, presents a unique challenge, especially for individuals with mobility impairments. In contrast to rigid-ground walking, compliant surfaces alter movement dynamics and increase the risk of falls. Understanding and modeling gait control across such soft and deformable surfaces is thus crucial for maintaining daily mobility.
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