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Nanocrystals in Dermal Drug Delivery: A Breakthrough for Enhanced Skin Penetration and Targeted Skin Disorder Treatments.
Pharmaceutics
December 2024
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
One of the major challenges in dermal drug delivery is the adequate penetration of the active compound into the skin without causing any skin irritation and inflammation. Nanocrystals (NCs) are nanoscale particles, and their sizes are below 1000 nm. NCs are made up of drug particles only, which are used to improve the aqueous solubility and bioavailability of poorly water-soluble drugs.
View Article and Find Full Text PDFClinical and Dermoscopic Evaluation of Patients With Topical Steroid Damaged Faces (TSDF).
Cureus
November 2024
Dermatology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, IND.
Background Topical steroid-dependent or damaged face (TSDF) is a common condition where the widespread availability of over-the-counter topical corticosteroid (TCS)-containing products leads to their misuse and addiction. Prolonged use of these steroids on the face can result in significant side effects. Early diagnosis and cessation of steroid use are important.
View Article and Find Full Text PDFSerum 5-S-cysteinyldopa as a predictive biomarker for stem cell transplantation-related complications in children and young adults.
Blood Cell Ther
November 2024
Department of Pediatrics, Graduate School of Medicine, Hokkaido University, Japan.
Diffuse hyperpigmentation is common in patients who undergo chemotherapy or stem cell transplantation (SCT). However, only a few studies have reported the relation between skin reactions and SCT-related complications. Serum 5-S-cysteinyldopa (5SCD), a pheomelanin precursor, is elevated in individuals with hyperpigmentation.
View Article and Find Full Text PDFAddisonian Pigmentation - The Great Mimicker - A Review.
Indian J Dermatol
October 2024
Department of Radiology, Institute of Liver and Biliary Sciences, New Delhi, India.
Skin colour usually depends upon melanin, haemoglobin, and carotenoids. Pigmentary disorders indicate an increased amount of melanin, leading to a darker colour of the skin, called hypermelanosis. Addison's disease is a rare endocrinal disorder with severe oral and systemic manifestations.
View Article and Find Full Text PDFVolatiles extracted from Melaleuca Rugulosa (Link) Craven leaves: comparative profiling, bioactivity screening, and metabolomic analysis.
BMC Complement Med Ther
November 2024
Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt.
Background: Melaleuca species (family Myrtaceae) are characterized by their wide-ranging applications as antimicrobials and in skin-related conditions. Herein, we estimated the volatile profile and biological significance of M. rugulosa (Link) leaves for the first time supported by a dereplication protocol.
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