Sesquiterpene lactones from Harv. and their cytotoxicity.

Nat Prod Res

Department of Paraclinical Sciences, Faculty of Veterinary Science, Onderstepoort, University of Pretoria, Pretoria, South Africa.

Published: July 2021

poisoning, referred to as 'vermeersiekte' is an important plant poisoning in southern Africa. Three sesquiterpene lactones, isogeigerin acetate () ivalin () and geigerin () were isolated and purified from Harv. (Asteraceae). Structures were deduced using 1 and 2D NMR spectroscopy and mass spectrometry, while the absolute configurations of compounds and were determined for the first time by X-ray crystal diffraction analyses. Cytotoxicity of isogeigerin acetate, ivalin and geigerin were compared by exposing a murine skeletal myoblast (C2C12) cell line to varying concentrations of the three sesquiterpene lactones isolated. Cell viability was assessed using the methyl-thiazolyl-tetrazolium (MTT) assay. The ECs were 3.746, 0.0029 and 3.792 mM for isogeigerin acetate (), ivalin () and geigerin (), respectively. The results indicate that ivalin is much more toxic, approximately 1000 times, compared to isogeigerin acetate and geigerin.

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http://dx.doi.org/10.1080/14786419.2019.1675068DOI Listing

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Sesquiterpene lactones from Harv. and their cytotoxicity.

Nat Prod Res

July 2021

Department of Paraclinical Sciences, Faculty of Veterinary Science, Onderstepoort, University of Pretoria, Pretoria, South Africa.

poisoning, referred to as 'vermeersiekte' is an important plant poisoning in southern Africa. Three sesquiterpene lactones, isogeigerin acetate () ivalin () and geigerin () were isolated and purified from Harv. (Asteraceae).

View Article and Find Full Text PDF

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