Objective: The objective was to explore the association of methylene tetrahydrofolate reductase () C667T and A1298C and reduced folate carrier 1 () A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China.
Methods: Two hundred ninety-six patients with RA were enrolled (cases) and 120 healthy individuals served as controls. The genotypes of C667T and A1298C SNP and A80G SNP were detected by restriction fragment length polymorphism-PCR and compared between cases and controls. We analyzed correlations of clinical effect, toxicity, and SNPs after 6 months of MTX treatment.
Results: We detected no significant differences in C677T and A1298C and A80G SNPs between cases and controls. The A80G SNP differed between RA patients with good and poor efficacy after 6 months of MTX, and was an independent factor of MTX efficacy. The C677T SNP was differently distributed in the adverse drug reaction (ADR) and non-ADR groups and was an independent factor of MTX toxicity.
Conclusions: In Chinese Han patients with RA, the C667T SNP may correlate with MTX toxicity, whereas the A80G SNP may correlate with MTX efficacy rather than toxicity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607194 | PMC |
| http://dx.doi.org/10.1177/0300060519879588 | DOI Listing |
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