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| http://dx.doi.org/10.14309/crj.0000000000000052 | DOI Listing |
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Lymphocytic Esophagitis: A Histologic Pattern of Various Underlying Disorders.
J Clin Gastroenterol
October 2024
Department of Pathology, School of Medicine, Lebanese American University, Byblos, Lebanon.
Background: Lymphocytic esophagitis (LyE) is a rare condition that has been reported in several case studies, but its diagnostic criteria and clinical significance are inconsistent. There are no established clinical associations, except for Crohn's disease in children. Our study aimed to determine if patients with LyE have distinct demographic or clinical characteristics when compared with patients with increased intraepithelial lymphocytes (IEL) in their esophageal biopsy.
View Article and Find Full Text PDFA New Differential Gene Expression Based Simulated Annealing for Solving Gene Selection Problem: A Case Study on Eosinophilic Esophagitis and Few Other Gastro-intestinal Diseases.
Biochem Genet
December 2024
Department of CSE, Meghnad Saha Institute of Technology, Behind Urbana Complex Near Ruby General Hospital, Anandapur Rd, Uchhepota, Kolkata, West Bengal, 700150, India.
Identifying the set of genes collectively responsible for causing a disease from differential gene expression data is called gene selection problem. Though many complex methodologies have been applied to solve gene selection, formulated as an optimization problem, this study introduces a new simple, efficient, and biologically plausible solution procedure where the collective power of the targeted gene set to discriminate between diseased and normal gene expression profiles was focused. It uses Simulated Annealing to solve the underlying optimization problem and termed here as Differential Gene Expression Based Simulated Annealing (DGESA).
View Article and Find Full Text PDFLow Incidence of Macular Edema and Other Ocular Events in the Etrasimod Development Program.
J Crohns Colitis
November 2024
IBD Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Article Synopsis
- Etrasimod is a selective oral drug that has been linked to a potential increased risk of macular edema, a condition affecting the eye.
- In a clinical study focusing on patients with conditions like ulcerative colitis and Crohn's disease, the rate of macular edema associated with etrasimod was similar to that of a placebo, with very few cases reported.
- Overall, macular edema and other eye-related issues were rare among patients taking etrasimod, and most related side effects were not serious.
Crohn's Disease Confined to the Esophagus, with No Involvement of the Small or Large Bowel.
Eur J Case Rep Intern Med
October 2024
Department of Gastroenterology, University of Balamand, Beirut, Lebanon.
Unlabelled: Crohn's disease (CD) is a transmural inflammatory process that can affect any segment of the gastrointestinal tract. CD has a predilection for the colon and the small bowel, specifically the terminal ileum. Esophageal involvement of CD is exceedingly rare and there is a paucity of data regarding the disease phenotypes, course, complications and treatment.
View Article and Find Full Text PDFIntroduction: Lymphocytic esophagitis (LyE) is a rare esophageal disorder of unknown etiology, characterized by dense peripapillary lymphocytes without neutrophils or eosinophils, and spongiosis. Patients typically present with symptoms such as dysphagia or chest pain. Here, we describe a notable case of lymphocytic esophagitis in a patient who presented with food impaction.
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