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Antimicrobial susceptibility of Clostridium botulinum group III field strains isolated in Europe from animal outbreaks.
Vet Microbiol
November 2024
Istituto Zooprofilattico Sperimentale delle Venezie, Microbiology and Veterinary Diagnostic Laboratory, Vicolo Mazzini 4, Villorba, Treviso 31020, Italy.
Neurotoxins produced by Clostridium (C.) botulinum group III are responsible for the majority of botulism outbreaks occurring in animals and in this study we report the drug susceptibility of 71 field strains. The minimum inhibitory concentration (MIC) of 13 antimicrobials was established through the agar dilution method.
View Article and Find Full Text PDFAssessment of Rifampicin Indeterminate Results among Adult Patients attending a Tertiary Tuberculosis Treatment Center in Port Harcourt Rivers State using Shewhart control Charts: Implications for patients and Tuberculosis Control Programs.
West Afr J Med
June 2024
Department of Community Medicine, River State University. Email: Tel: +2348033421555.
Background: Antimicrobial resistance is a growing global public health concern, and multidrug-resistant Tuberculosis is responsible for roughly one-quarter of all antimicrobial-resistant infection-related deaths worldwide. GeneXpert is a rapid, automated molecular test that detects multi-drug-resistant Tuberculosis using Rifampicin as a predictor. The World Health Organization (WHO) in 2010 recommended GeneXpert for national tuberculosis programs in developing countries; however, it has limitations.
View Article and Find Full Text PDFCryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.
Proc Natl Acad Sci U S A
September 2024
Shanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Drug-resistant Tuberculosis (TB) is a global public health problem. Resistance to rifampicin, the most effective drug for TB treatment, is a major growing concern. The etiological agent, (), has a cluster of ATP-binding cassette (ABC) transporters which are responsible for drug resistance through active export.
View Article and Find Full Text PDFEfficacy and treatment outcome of infected patients with pulmonary : A systematic review.
J Clin Tuberc Other Mycobact Dis
August 2024
Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Background: () is a non-tuberculosis bacterium with a highly prevalent that is transferred by aerosols from water and soil resources to the respiratory system. is one of the main species responsible for NTM pulmonary disease.
Methods: Web of Science, Scopus, and PubMed databases were systematically explored.
Adherence to preventive treatment for latent tuberculosis infection in close contacts of pulmonary tuberculosis patients: A cluster-randomized controlled trial in China.
Int J Infect Dis
October 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address:
Objectives: This study examined adherence rates to tuberculosis preventive treatment (TPT) among close contacts of individuals with pulmonary tuberculosis (PTB) and identified factors associated with TPT adherence in China.
Methods: A multicenter, cluster-randomized, open-label control trial was carried out across three sites involving 34 counties in China. Close contacts of bacteriologically confirmed rifampin and isoniazid-susceptible PTB cases were identified and screened for latent tuberculosis infection (LTBI).
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