Body segment parameters such as segment mass, center of mass, and radius of gyration are used as inputs in static and dynamic ergonomic and biomechanical models used to predict joint and muscle forces, and to assess risks of musculoskeletal injury. Previous work has predicted body segment parameters (BSPs) in the general population using age and obesity levels as statistical predictors (Merrill et al., 2017). Estimated errors in the prediction of BSPs can be as large as 40%, depending on age, and the prediction method employed (Durkin and Dowling, 2003). Thus, more accurate and representative segment parameter inputs are required for attempting to predict modeling outputs such as joint contact forces, muscle forces, and injury risk in individuals. This study aims to provide statistical models for predicting torso, thigh, shank, upper arm, and forearm segment parameters in working adults using whole body dual energy x-ray absorptiometry (DXA) scan data along with a set of anthropometric measurements. The statistical models were developed on a training data set, and independently validated on a separate test data set. The predicted BSPs in validation data were, on average, within 5% of the actual in vivo DXA-based BSPs, while previously developed predictions (de Leva, 1996) had average errors of up to 60%, indicating that the new models greatly increase the accuracy in predicting segment parameters. These final developed models can be used for calculating representative BSPs in individuals for use in modeling applications dependent on these parameters.
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http://dx.doi.org/10.1016/j.jbiomech.2019.109349 | DOI Listing |
Eur J Orthod
December 2024
Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
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View Article and Find Full Text PDFCirc Cardiovasc Imaging
January 2025
Division of Cardiology, Department of Medicine, University of California, San Francisco (L.C., S.D., D.B., J.J.T., Q.F., L.T., A.H.R., R.J., S.H., H.H.H., Z.H.T., N.B.S., F.N.D.).
Background: A subset of patients with mitral valve prolapse (MVP), a highly heritable condition, experience sudden cardiac arrest (SCA) or sudden cardiac death (SCD). However, the inheritance of phenotypic imaging features of arrhythmic MVP remains unknown.
Methods: We recruited 23 MVP probands, including 9 with SCA/SCD and 14 with frequent/complex ventricular ectopy.
Imaging-based spatial transcriptomics (ST) is evolving rapidly as a pivotal technology in studying the biology of tumors and their associated microenvironments. However, the strengths of the commercially available ST platforms in studying spatial biology have not been systematically evaluated using rigorously controlled experiments. In this study, we used serial 5-m sections of formalin-fixed, paraffin-embedded surgically resected lung adenocarcinoma and pleural mesothelioma tumor samples in tissue microarrays to compare the performance of the single cell ST platforms CosMx, MERFISH, and Xenium (uni/multi-modal) platforms in reference to bulk RNA sequencing, multiplex immunofluorescence, GeoMx Digital Spatial Profiler, and hematoxylin and eosin staining data for the same samples.
View Article and Find Full Text PDFJ Imaging Inform Med
January 2025
Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Seoul, 05505, Republic of Korea.
Although the relationships between basic clinical parameters and white matter hyperintensity (WMH) have been studied, the associations between vascular factors and WMH volume in general populations remain unclear. We investigated the associations between clinical parameters including comprehensive vascular factors and WMH in two large general populations. This retrospective, cross-sectional study involved two populations: individuals who underwent general health examinations at the Asan Medical Center (AMC) and participants from a regional cohort, the Korean Genome and Epidemiology Study (KoGES).
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Electronic Information and Physics, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Accurate segmentation of retinal blood vessels from retinal images is crucial for detecting and diagnosing a wide range of ophthalmic diseases. Our retinal blood vessel segmentation algorithm enhances microfine vessel extraction, improves edge texture clarity, and normalizes vessel distribution. It stabilizes neural network training for complex retinal vascular features.
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