Tyrosine Kinases in Infections and Gastric Cancer.

Toxins (Basel)

Cancer Cluster Salzburg, Department of Biosciences, Paris-Lodron University of Salzburg, 5020 Salzburg, Austria.

Published: October 2019

() has been identified as a leading cause of gastric cancer, which is one of the most frequent and malignant types of tumor. It is characterized by its rapid progression, distant metastases, and resistance to conventional chemotherapy. A number of receptor tyrosine kinases and non-receptor tyrosine kinases have been implicated in -mediated pathogenesis and tumorigenesis. In this review, recent findings of deregulated EGFR, c-Met, JAK, FAK, Src, and c-Abl and their functions in pathogenesis are summarized.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832112PMC
http://dx.doi.org/10.3390/toxins11100591DOI Listing

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