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The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. | LitMetric

AI Article Synopsis

  • Chloroplasts respond to proteotoxic stress by activating a communication process with the nucleus known as the chloroplast unfolded protein response (cpUPR).
  • Researchers identified a mutant that disrupts cpUPR signaling and discovered a new gene, Mars1, crucial for this signaling pathway.
  • The study reveals that inducing cpUPR enhances cell resilience to chloroplast stress, suggesting that modifying this pathway could lead to improved photosynthetic organisms that can better handle stress.

Article Abstract

In response to proteotoxic stress, chloroplasts communicate with the nuclear gene expression system through a chloroplast unfolded protein response (cpUPR). We isolated mutants that disrupt cpUPR signaling and identified a gene encoding a previously uncharacterized cytoplasmic protein kinase, termed Mars1-for utant ffected in chloroplast-to-nucleus etrograde ignaling-as the first known component in cpUPR signal transmission. Lack of cpUPR induction in mutant cells impaired their ability to cope with chloroplast stress, including exposure to excessive light. Conversely, transgenic activation of cpUPR signaling conferred an advantage to cells undergoing photooxidative stress. Our results indicate that the cpUPR mitigates chloroplast photodamage and that manipulation of this pathway is a potential avenue for engineering photosynthetic organisms with increased tolerance to chloroplast stress.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794094PMC
http://dx.doi.org/10.7554/eLife.49577DOI Listing

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