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| http://dx.doi.org/10.1080/10428194.2019.1675876 | DOI Listing |
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Mantle cell lymphoma with EBV-positive Hodgkin and Reed-Sternberg-like cells in a patient after autologous PBSCT: Phenotypically distinct but genetically related tumors.
Pathol Int
January 2021
Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
The case of 70-year-old man with mantle cell lymphoma (MCL) carrying t(11;14) translocation that relapsed as nodal lymphoma combining MCL and classic Hodgkin lymphoma (cHL) 9 years after autologous peripheral blood stem cell transplant (auto-PBSCT) is reported. Lymph nodes contained two separate areas of MCL and cHL-like components. Hodgkin and Reed-Sternberg (HRS)-like cells were accompanied by a prominent histiocyte background.
View Article and Find Full Text PDF[Sequential development of mantle cell lymphoma following chronic lymphocytic leukemia].
Rinsho Ketsueki
May 2020
Department of Hematology, Kin-ikyo Chuo Hospital.
Richter syndrome (RS) is the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Most cases of diffuse large B-cell lymphoma variant of RS are clonally related to the original CLL. Here, we present a case of mantle cell lymphoma (MCL) that developed sequentially during the clinical course of CLL.
View Article and Find Full Text PDFClonally-Related CD5+ CLL/SLL and CD10+ high grade B-cell lymphoma suggests common neoplastic progenitor with branched disease evolution, with therapeutic implications.
Leuk Lymphoma
February 2020
Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements.
Case Rep Hematol
December 2018
Medical Oncology and Hematology, 7777 Milliken Avenue Suite 210, Rancho Cucamonga, CA 91730, USA.
Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow.
View Article and Find Full Text PDFDynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones.
Exp Hematol
February 2017
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK. Electronic address:
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonally derived mature CD5 B cells; however, the cellular origin of CLL is still unknown. Patients with CLL also harbor variable numbers of CD5 B cells, but the clonal relationship of these cells to the bulk disease is unknown and can have important implications for monitoring, treating, and understanding the biology of CLL. Here, we use B-cell receptors (BCRs) as molecular barcodes to first show by single-cell BCR sequencing that the great majority of CD5 B cells in the blood of CLL patients are clonally related to CD5 CLL B cells.
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