Objective: Recently, the US Food and Drug Administration investigated the contamination of kratom (Mitragyna speciosa) by , an event that caused an outbreak in 20 states after its consumption. Therefore, we investigated 16 different bags of kratom submitted for testing for potential contamination with and other microorganisms within the Public Health Laboratory for the state of South Carolina.
Materials And Methods: All kratom powders collected were analyzed for potential contamination with bacteria by an in-house modified Food and Drug Administration's Bacteriological Analytical Manual procedure.
Results: Out of 16 products analyzed, six brands have unknown manufacturers, but manufacturer information was available for the other 10 products. In total, three brands of kratom showed presence of any .
Conclusions: Recently analyzed kratom products show a presence of .
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Clin Toxicol (Phila)
October 2024
Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA.
Introduction: Kratom is commonly used by consumers, and the elemental impurity exposure that consumers would have at different kratom ingestion doses has been determined.
Methods: This assessment used original data from independent third-party laboratory testing of kratom products to identify the percentage of products that exceeded permissible daily exposure limits for lead (5 µg/day), nickel (200 µg/day), arsenic (15 µg/day), and cadmium (5 µg/day), the interim reference level for lead in adults (12.5 µg/day), and the tolerable upper intake level for manganese (11 mg/day) and nickel (1 mg/day).
Curr Opin Anaesthesiol
October 2024
UVA Health Department of Anesthesiology, Charlottesville, Virginia, USA.
Purpose Of Review: Kratom is used commonly in the United States, usually to mitigate pain, opioid withdrawal, or fatigue. A comprehensive discussion on kratom, tailored to pain management physicians, is needed, given its associated risks and potential interactions.
Recent Findings: Kratom and its main metabolites, mitragynine and 7-OH-mitragynine, bind to a variety of receptors including mu opioid receptors.
J Psychoactive Drugs
October 2024
Department of Clinical, Pharmacological and Biological Sciences, College Lane, University of Hertfordshire, Hatfield, UK.
In recent years, the online sale of kratom (), a Southeast Asian plant with both medicinal and psychoactive properties, has raised health concerns mainly due to the uncontrolled diffusion of adulterated kratom-related products. This exploratory study provides, for the first time, a snapshot of the availability of kratom products on the darknet which has been further validated by data searches on the surface web. A total of 231 listings of kratom across 23 darknet marketplaces were identified between March 2020 and October 2021.
View Article and Find Full Text PDFCurr Addict Rep
May 2023
Department of Psychology and Cognitive Science, University of Trento, Corso Bettini, 84, 38068 Rovereto, Italy.
Purpose Of Review: This work aims to provide an up-to-date review of the preclinical and clinical scientific literature on the therapeutic value of kratom to better understand the underlying mechanisms related to its use and inform future therapeutic applications.
Recent Findings: A growing number of studies, mainly of cross-sectional nature, describe the widespread use of kratom by individuals to self-treat pain, psychiatric symptoms, and substance use disorders (SUD) outside a controlled clinical setting. Preclinical evidence suggests kratom is effective as an analgesic agent and might decrease the self-administration of other drugs.
Foodborne Pathog Dis
September 2022
Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
In early 2018, we investigated a large national multiple-serotype outbreak linked to contaminated kratom, a raw minimally processed botanical substance. Kratom is a plant consumed for its stimulant effects and as an opioid substitute. A case was defined as a laboratory-confirmed infection with one of the outbreak strains (serotypes I 4,[5],12:b:-, Heidelberg, Javiana, Okatie, Weltevreden, or Thompson) with illnesses onset during January 11, 2017-May 8, 2018.
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