AI Article Synopsis
- Tongue squamous cell carcinoma (TSCC) is a highly aggressive type of oral cancer associated with low survival rates due to lymph node and distant organ metastasis.
- Research is increasingly focusing on the molecular mechanisms underlying TSCC, particularly the role of long noncoding RNA (lncRNA) in tumor development and progression.
- lncRNA influences TSCC cell behavior, including proliferation, invasion, and migration, through various methods and mechanisms, and this article reviews recent findings on these molecular interactions.
Article Abstract
Tongue squamous cell carcinoma (TSCC) is the most common and highly malignant oral squamous cell carcinoma (OSCC) with lymph node metastasis or distant organ metastasis and, thus, low overall survival rates. Studies on the molecular mechanism of the biologic characteristics of TSCC and exploration of targeted therapies have become the frontiers in the research of this disease. Long noncoding RNA (lncRNA), a type of noncoding RNA, plays a key role in the occurrence and development of tumors. In recent years, more and more studies on lncRNA have been focusing on tongue cancer. lncRNA affects the proliferation, invasion, and migration of TSCC cells through a variety of methods and molecular mechanisms. With reference to recent reports, this article provides an overview of the molecular mechanisms of various lncRNAs and their functions in TSCC.
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| http://dx.doi.org/10.1016/j.oooo.2019.08.011 | DOI Listing |
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