The risk factors of concussion may be categorized as intrinsic (internal factors specific to the individual) or extrinsic (external factors related to the environment or sport). Identifying these factors is part of an individualized, patient-centered approach to prevention, assessment, and management of concussion. In most cases, the symptoms of concussion resolve in the initial few days following the injury, and a strategy involving a gradual return to sport and school is recommended. When symptoms persist for longer than 7 to 10 days, a multifaceted interdisciplinary assessment to guide treatment is recommended. This article applies the dynamic, recursive model of sport injury to sport-related concussion and summarizes the process of individualized assessment and management following concussion in athletes of all ages, with a focus on physical rehabilitation. .
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http://dx.doi.org/10.2519/jospt.2019.8926 | DOI Listing |
Sci Rep
January 2025
Department of Electronics and Communication Engineering, Panimalar Engineering College, Chennai, India.
Chaos
January 2025
School of Mathematical Science, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
This study explores the impact of stochastic resetting on the random walk dynamics within scale-free (u,v)-flowers. Utilizing the generating function technique, we develop a recursive relationship for the generating function of the first passage time and establish a connection between the mean first passage time with and without resetting. Our investigation spans multiple scenarios, with the random walker starting from various positions and aiming to reach different target nodes, allowing us to identify the optimal resetting probability that minimizes the mean first passage time for each case.
View Article and Find Full Text PDFMol Biol Cell
January 2025
Laboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
The transmembrane glycoproteins Trop-1/EpCAM and Trop-2 independently trigger Ca and kinase signals for cell growth and tumor progression. Our findings indicated that Trop-1 and Trop-2 tightly colocalize at macroscopic, ruffle-like protrusions (RLP), that elevate from the cell perimeter, and locally recur over hundreds of seconds. These previously unrecognized elevated membrane regions ≥20 µm-long, up to 1.
View Article and Find Full Text PDFIn Silico Pharmacol
January 2025
Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Unlabelled: The implication of matrix metalloproteinase-12 (MMP-12) in various major disorders including cancer, COPD, cardiovascular disorders, and neurological diseases makes it a potential target for drug discovery. Contemplating the significance of MMP-12, a number of MMP-12 inhibitors were designed, synthesized and tested throughout the world but the non-selective nature of most of those molecules can lead to adverse drug interactions. In contradiction, the dibenzofuran (DBF) and dibenzothiophene (DBT) derivatives showed highly potent and selective MMP-12 inhibition.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Department of Accounting and Finance, Nottingham Trent University, Nottingham, UK. Electronic address:
In the context of global sustainability goals, it is imperative to examine the interplay between emerging financial technologies and environmental objectives, which in turn offers insights into the implications of such technologies on sustainable investments and environmental policy decisions. Accordingly, this study investigates the influence of Bitcoin's energy consumption (BEC), as a representative of the cryptocurrency market, on the regional green economy indices of the United States, Europe, and Asia. Utilizing both unfiltered and filtered data, we conduct empirical analyses from both static and dynamic perspectives to account for the causal relationships that emerged during critical market developments, employing novel algorithms including forward recursive, rolling windows, and recursive rolling.
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