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Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness.
J Physiol Sci
January 2025
Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, 950-3198, Niigata, Japan; Institute for Human Movement and Medical Sciences (IHMMS), Niigata University of Health and Welfare, 950-3198, Niigata, Japan.
We reviewed fundamental studies on muscular pain, encompassing the characteristics of primary afferent fibers and neurons, spinal and thalamic projections, several muscular pain models, and possible neurochemical mechanisms of muscle pain. Most parts of this review were based on data obtained from animal experiments, and some researches on humans were also introduced. We focused on delayed-onset muscle soreness (DOMS) induced by lengthening contractions (LC), suitable for studying myofascial pain syndromes.
View Article and Find Full Text PDFApplying a sustainability perspective in the literature on physical therapy in relation to pharmaceuticals: a scoping review.
Front Public Health
January 2025
Department of General Practice, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Introduction: Physical therapy encompasses a broad range of treatment options, often utilized in clinical settings where pharmaceutical interventions are standard. The potential for physical therapy to contribute to sustainable healthcare by reducing environmental impact, while maintaining the quality of care, remains underexplored. This study aimed to map existing research comparing physical therapy to pharmaceuticals, with a specific focus on whether these studies address aspects of sustainable development.
View Article and Find Full Text PDFHypotonic Swelling Method for the Isolation of Pure Mitochondria From Primary Human Skeletal Myoblasts for Proteomic Studies.
J Cell Mol Med
January 2025
Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Mitochondria play a fundamental role in energy metabolism, particularly in high-energy-demand tissues such as skeletal muscle. Understanding the proteomic composition of mitochondria in these cells is crucial for elucidating the mechanisms underlying muscle physiology and pathology. However, effective isolation of mitochondria from primary human skeletal muscle cells has been challenging due to the complex cellular architecture and the propensity for contamination with other organelles.
View Article and Find Full Text PDFDifferences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-Analysis.
Musculoskeletal Care
March 2025
Jordan University Hospital, School of Medicine, University of Jordan, Amman, Jordan.
Background: Fibromyalgia-one of the chronic pain syndromes-characterised by pain, fatigue, and tenderness. The role of certain micronutrients like vitamin D, vitamin B12, and ferritin has been previously investigated in many primary studies aiming to assess both their therapeutic and diagnostic potential in the management of fibromyalgia.
Aim: To compare the levels of vitamin D, ferritin, and vitamin B12 between fibromyalgia patients and healthy controls.
Carpal Tunnel, Trigger Finger, and Spinal Stenosis: The Rest of the Story.
S D Med
November 2024
Sanford Orthopedics and Sports Medicine, Sioux Falls, South Dakota.
Amyloidosis is a deadly systemic disease in which misfolded proteins accumulate in human tissue eventually leading to morbid dysfunction in multiple organ systems. The prognosis of untreated amyloidosis is poor. Orthopedic manifestations of amyloidosis include carpal tunnel syndrome (CTS), trigger digit, distal biceps tendon rupture, rotator cuff disease, and lumbar spinal stenosis.
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