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| http://dx.doi.org/10.1038/s41423-019-0302-5 | DOI Listing |
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Monocytes give rise to Langerhans cells that preferentially migrate to lymph nodes at steady state.
Proc Natl Acad Sci U S A
November 2024
Microbiology and Immunology Department, Stanford University School of Medicine, Stanford, CA 94305.
Current evidence suggests that ontogeny may account for the functional heterogeneity of some tissue macrophages, but not others. Here, we asked whether developmental origin drives different functions of skin Langerhans cells (LCs), an embryo-derived mononuclear phagocyte with features of both tissue macrophages and dendritic cells. Using time-course analyses, bone marrow chimeras, and fate tracing models, we found that the complete elimination of embryo-derived LCs at steady state results in their repopulation from circulating monocytes.
View Article and Find Full Text PDFLangerhans Cell Histiocytosis or Acute Cellular Rejection?
Pediatr Transplant
December 2024
Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Background: Langerhans cell histiocytosis (LCH) is a rare malignant disorder of epidermal antigen presenting cells. It is characterized by infiltration of various tissues with dendritic cells (Langerhans cells, LC) that express CD1a or CD207 (langerin), often leading to organ dysfunction. A patient with LCH required liver transplantation (LT) for LCH-associated biliary-tract disease.
View Article and Find Full Text PDFA case of indeterminate cell histiocytosis with ETV3-NCOA2 translocation.
J Dermatol
November 2024
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Indeterminate cell histiocytosis (ICH) is a rare histiocytic disorder characterized by a proliferation of CD1a and CD207/langerin cells. Recent molecular analyses have identified ETV3-NCOA2 translocation as a possible aetiopathogenesis of ICH. Herein, we describe the first Japanese case of ICH with ETV3-NCOA2 translocation.
View Article and Find Full Text PDFLangerhans cell histiocytosis in an infant.
Pediatr Pulmonol
October 2024
Department of Gastroenterology and Pediatric Endoscopy Center, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
A 2-month-old male infant presented with a persistent mild cough and a pink papule beneath the left eyelid. Imaging studies revealed diffuse lung opacities and a cystic shadow in the right middle lobe, with no evidence of bacterial or fungal infection. Skin biopsy demonstrated positive immunohistochemical staining for CD207/Langerin and CD1a, leading to a diagnosis of Langerhans-cell histiocytosis (LCH).
View Article and Find Full Text PDFIndeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms.
Blood Adv
November 2024
Department of Pathology, Ambroise-Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), & EA4340-Biomarkers and clinical trials in Cancerology and Onco-Hematology, Versailles SQY University, Paris-Saclay University, Boulogne, France.
Article Synopsis
- Indeterminate dendritic cell histiocytosis (IDCH) is a rare condition marked by a buildup of specific histiocytes, with particular immunophenotypic features and clinical presentations, mostly in older adults.
- The study analyzed 43 cases, showing that many patients had skin or lymph node involvement, and a significant number had related blood cancers or other histiocytic diseases.
- Genetic analyses identified common mutations (like KRAS and BRAF) and unique gene fusions, helping to clarify IDCH's molecular profile and its potential impact on diagnosis and treatment strategies.
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