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| http://dx.doi.org/10.1038/s41422-019-0235-7 | DOI Listing |
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DDX18 influences chemotherapy sensitivity in colorectal cancer by regulating genomic stability.
Exp Cell Res
January 2025
Department of Oncology, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, 410000, China; Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, China; Hunan Hepatobiliary and Pancreatic Cancer Clinical Medical Research Center, China. Electronic address:
Chromosomal Instability (CIN) encompasses approximately 65 %-70 % of colorectal cancer (CRC) patients, playing a pivotal role in tumor progression. However, controversies persist regarding the molecular characteristics and treatment strategies associated with these patients. Integrative colorectal cancer proteogenomic analysis identified DDX18 in colorectal cancer.
View Article and Find Full Text PDFThe molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability.
J Biol Chem
November 2024
Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, USA; Materials Science, Engineering, and Commercialization (MSEC) Program, Texas State University, San Marcos, Texas, USA. Electronic address:
Unscheduled R-loops usually cause DNA damage and replication stress, and are therefore a major threat to genome stability. Several RNA processing factors, including the conserved THO complex and its associated RNA and DNA-RNA helicase UAP56, prevent R-loop accumulation in cells. Here, we investigate the function of ALYREF, an RNA export adapter associated with UAP56 and the THO complex, in R-loop regulation.
View Article and Find Full Text PDFDysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma.
Apoptosis
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Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, Guizhou Medical University, Guiyang, China.
Dysregulated R-loop homeostasis leads to DNA replication stress and genomic instability, a major driver of cancer. However, the role of R-loops in melanoma development remains unclear. We established an R-loop scoring model based on a single-cell RNA sequencing dataset and evaluated the association between the R-loop score with the melanoma immune microenvironment and treatment response.
View Article and Find Full Text PDFGlobal coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila.
Nucleic Acids Res
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RNA Institute, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Article Synopsis
- * Researchers modified a technique to analyze R-loops in Drosophila and discovered that unlike in mammals, high GC content isn't necessary for R-loop formation in these flies; instead, the presence of RNAPII is a key factor across different gene regions.
- * The study found that alterations in Spt6 affect R-loop levels and gene expression, impacting developmental processes, while increasing rnh1 levels can mitigate issues like DNA damage and developmental defects, indicating a significant role of R-loops in regulating gene activity and genome stability.
Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks.
Nucleic Acids Res
November 2024
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
DNA double-strand breaks (DSBs) represent a lethal form of DNA damage that can trigger cell death or initiate oncogenesis. The activity of RNA polymerase II (RNAPII) at the break site is required for efficient DSB repair. However, the regulatory mechanisms governing the transcription cycle at DSBs are not well understood.
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