Sex differences among neurones in the ventrolateral region of the ventromedial hypothalamic nucleus (VMHvl) allow for the display of a diversity of sex-typical behaviours and physiological responses, ranging from mating behaviour to metabolism. Here, we review recent studies that interrogate the relationship between sex-typical responses and changes in cellular phenotypes. We discuss technologies that increase the resolution of molecular profiling or targeting of cell populations, including single-cell transcriptional profiling and conditional viral genetic approaches to manipulate neurone survival or activity. Overall, emerging studies indicate that sex-typical functions of the VMH may be mediated by phenotypically distinct and sexually differentiated neurone populations within the VMHvl. Future studies in this and other brain regions could exploit cell-type-specific tools to reveal the cell populations and molecular mediators that modulate sex-typical responses. Furthermore, cell-type-specific analyses of the effects of sexually differentiating factors, including sex hormones, can test the hypothesis that distinct cell types within a single brain region vary with respect to sexual differentiation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982598 | PMC |
| http://dx.doi.org/10.1111/jne.12801 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Epithelial and mesenchymal compartments of the developing bladder and urethra display spatially distinct gene expression patterns.
Dev Biol
January 2025
Institute for Stem Cell Science and Regenerative Medicine (iBRIC-inStem), GKVK-Post, Bellary Road, Bengaluru, Karnataka 560065, India. Electronic address:
The lower urinary tract is comprised of the bladder and urethra and develops from the cloaca, a transient endoderm-derived structure formed from the caudal hindgut. After cloacal septation to form the urogenital sinus and anorectal tract, the bladder gradually develops from the anterior portion of urogenital sinus while the urethra elongates distally into the genital tubercle. The bladder is a target for regenerative and reconstructive therapies but engineering an impermeable bladder epithelial lining has proven challenging.
View Article and Find Full Text PDFPTSD and CPTSD in the new ICD-11 - A latent profile analysis.
Psychiatry Res
January 2025
Clinic for Psychosomatic Medicine and Psychotherapy, University of Duisburg-Essen, LVR-University Hospital Essen, Essen, Germany; Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University of Duisburg-Essen, Essen, Germany.
In the 11th version of the WHO´s International Classification of Diseases, complex post-traumatic stress disorder (CPTSD) is newly recognized as a variant of PTSD, characterized by additional and more severe symptoms and typically arising from prolonged or multiple traumatic experiences. Despite recent research supporting the differentiation between PTSD and CPTSD, studies also identify a third or even a fourth latent profile in trauma patients. This study employs latent profile analysis to identify the number of latent profiles within a clinical trauma population in Germany (N = 588) and aims to investigate their distinct symptomatology.
View Article and Find Full Text PDFFirst evidence of molecular response of the shrimp Hippolyte inermis to biodegradable microplastics.
J Hazard Mater
December 2024
Stazione Zoologica Anton Dohrn, Department of Ecosustainable Marine Biotechnology, Ischia Marine Centre, Via Francesco Buonocore, 42, Ischia 80077, Italy.
The increasing demand for sustainable alternatives to conventional plastics has propelled the interest in bioplastics. A few papers reported on the effects of plastics on crustaceans, but no indication about biodegradable polymers is available. Hippolyte inermis Leach, 1816 is a protandric shrimp commonly living on leaves of the seagrass Posidonia oceanica, in the Mediterranean Sea.
View Article and Find Full Text PDFNew insights into the interplay between MALAT1 and miRNA-155 to unravel potential diagnostic and prognostic biomarkers of Behçet's disease.
Clin Rheumatol
January 2025
Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
The current study was deployed to evaluate the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miR-155, along with the inflammatory markers, TNFα and IL-6, and the adhesion molecule, cluster of differentiation 106 (CD106), in Behçet's disease (BD) pathogenesis. The study also assessed MALAT1/miR-155 as promising diagnostic and prognostic biomarkers for BD. The current retrospective case-control study included 74 Egyptian BD patients and 50 age and sex-matched controls.
View Article and Find Full Text PDFLactoferrin Attenuates Pro-Inflammatory Response and Promotes the Conversion into Neuronal Lineages in the Astrocytes.
Int J Mol Sci
January 2025
Department of Biosciences, Biotechnologies and Environment, University of Bari, 70125 Bari, Italy.
Neurodegenerative diseases are characterized by progressive loss of neurons and persistent inflammation. Neurons are terminally differentiated cells, and lost neurons cannot be replaced since neurogenesis is restricted to only two neurogenic niches in the adult brain, whose neurogenic potential decreases with age. In this regard, the astrocytes reprogramming into neurons may represent a promising strategy for restoring the lost neurons and rebuilding neural circuits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!