V-domain Ig suppressor of T cell activation (VISTA) is a novel checkpoint regulator with limited homology to other B7 family members. The constitutive expression of VISTA on both the myeloid and T lymphocyte lineages coupled to its important role in regulating innate and adaptive immune responses, qualifies VISTA to be a promising target for immunotherapeutic intervention. Studies have shown differential impact of agonistic and antagonistic targeting of VISTA, providing a unique landscape for influencing the outcome of cancer and inflammatory diseases.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233310 | PMC |
| http://dx.doi.org/10.1016/j.smim.2019.101308 | DOI Listing |
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