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http://dx.doi.org/10.4103/jcrt.JCRT_402_17 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
March 2025
B. D. Patel Institute of Paramedical Sciences, Charotar University of Science and Technology, CHARUSAT Campus, Changa, 388421, Gujarat, India.
Cancer continues to be the leading cause of mortality worldwide, with metastasis being the primary contributor to cancer-related deaths. Despite significant advancements in cancer therapies, metastasis remains a major challenge in effective cancer management. Metastasis, the process by which cancer cells spread from the primary tumor to distant organs, is a complex phenomenon influenced by multiple factors, including the human microbiota.
View Article and Find Full Text PDFRSC Adv
February 2025
Queensland University of Technology, Faculty of Engineering, School of Mechanical, Medical, and Process Engineering Brisbane QLD 4000 Australia
The rapid advancement of antibacterial nanostructured surfaces indicates that they will soon be integrated into real-world applications. However, despite notable progress, a comprehensive understanding of the antibacterial properties of nanostructures remains elusive, posing a critical barrier to the translation of this technology into practical applications. Among the numerous antibacterial nanostructures developed, nanowire structures play an important role due to their enhanced efficacy against bacteria and viruses and their ease of fabrication.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2024
Prediabetes is a critical health condition characterized by elevated blood glucose levels that fall below the threshold for Type 2 diabetes (T2D) diagnosis. Accurate identification of prediabetes is essential to forestall the progression to T2D among at-risk individuals. This study aims to pinpoint the most effective machine learning (ML) model for prediabetes prediction and to elucidate the key biological variables critical for distinguishing individuals with prediabetes.
View Article and Find Full Text PDFPathogens
February 2025
Centro Nacional de Innovaciones Biotecnológicas (CENIBiot), CeNAT, Conare, San José 1174-1200, Costa Rica.
Chagas disease, caused by , remains a significant public health challenge, particularly in Latin America, where it is one of the most neglected diseases and is primarily transmitted by triatomine insects. The disease exhibits complexity due to its diverse transmission routes, including vectorial and non-vectorial mechanisms such as blood transfusions and congenital transmission. Effective monitoring and control strategies are critical to mitigating its impact.
View Article and Find Full Text PDFDrug Deliv Transl Res
February 2025
Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
The advent of RNA interference (RNAi) technology through the use of short-interfering RNAs (siRNAs) represents a paradigm shift in the fight against viral infections. siRNAs, with their ability to directly target and silence specific posttranscriptional genes, offer a novel mechanism of action distinct from that of traditional pharmacotherapeutics. This review delves into the growing field of siRNA therapeutics against viral infections, highlighting their critical role in contemporary antiviral strategies.
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