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Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease.
Nutr Neurosci
October 2024
Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: Brain tissue in Alzheimer's patients is exposed to oxidative stress. Silymarin is an adjunct drug that has anti-inflammatory and antioxidant properties.
Objective: This study aimed to evaluate the effect of silymarin on biomarkers of oxidative stress, inflammation, and disease severity in Alzheimer's patients.
Knock-on effect of periodontitis to the pathogenesis of Alzheimer's disease?
Wien Klin Wochenschr
September 2020
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 4th Floor, Room M04-313, 6020, Innsbruck, Austria.
Background: Alzheimer's disease has chronic inflammatory components, which can be enhanced by systemic immune activation resulting in inflammation or vice versa. There is growing evidence that chronic periodontitis drives systemic inflammation and finally Alzheimer's disease. Thus, a link might exist between oral pathogens and Alzheimer's disease.
View Article and Find Full Text PDFKynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia.
Int J Tryptophan Res
September 2019
Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.
Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in patients with dementia.
Objective: The objective of this study was to assess associations between circulating kynurenines, cognitive prognosis, and neuropsychiatric symptoms.
Neopterin and mini-mental state examination scores in delirium: New insights?
J Cancer Res Ther
April 2020
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Neopterin and mini-mental state examination scores, two independent risk factors for postoperative delirium in elderly patients with open abdominal surgery.
J Cancer Res Ther
February 2019
Department of Anesthesiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
Background: Postoperative delirium is described as one of the most common complications for elderly patients with unknown pathophysiological pathways. In this present study, we analyzed the clinical and biochemical parameters in elderly patients with or without a delirium after open abdominal surgery to investigate the possible predicative factors for a delirium.
Materials And Methods: Patients aged ≥60 years scheduled to undergo elective gastrointestinal tumor resection via laparotomy from July 2012 to June 2015 were enrolled in this study.
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