Artificial indoor lighting can disturb sleep and increase depressive symptoms; both common complaints in psychiatric inpatients. In this trial we aimed to improve sleep in psychiatric inpatients using a circadian lighting environment. Investigator-blinded parallel-group randomised controlled effectiveness trial in an inpatient psychiatric ward with adjustable lighting. Admitted patients received a pre-set circadian lighting environment (intervention group) or lighting as usual (control group). The primary outcome was the Pittsburg Sleep Quality Index (PSQI) and secondary outcomes included the Major Depression Inventory and WHO-5 Well-Being Index. We assessed 74 patients and included 54 (27 treated and 27 controls). Treated patients reported a non-significant change in mean sleep quality by -1.02 points on the PSQI (95% CI: -3.17; 1.12) and controls by -0.59 points (95% CI: -2.52; 1.33), difference -0.43 (95% CI: -3.05; 2.2, -value .74). Similarly, treated patients reported a non-significant change in depressive symptoms and well-being compared to controls. Qualitative data indicated no serious side-effects and no patients in the intervention group were submitted to involuntary measures. Collection of data was non-complete and missing data from self-reported questionnaires amounted to 52.5%. The intervention showed no effect on sleep quality, mood or well-being. The circadian lighting environment was safe in our small and diverse patient sample. The trial integrated well with routine clinical care and our sample reflected the heterogeneity of the target population.
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http://dx.doi.org/10.1080/08039488.2019.1676465 | DOI Listing |
Med Vet Entomol
December 2024
Laboratory of Insects of Forensic Importance, Department of Zoology, Universidade Federal de Pernambuco, Recife, Brazil.
The nocturnal behaviour and reproduction patterns of Sarcophagidae species during the scotophase are largely unexplored for species in the Neotropical region. The aim of this study was to assess the light regimes under which females of Peckia (Peckia) chrysostoma (Wiedemann, 1830) and Peckia (Sarcodexia) lambens (Wiedemann, 1830) would larviposit and understand how these variables influence intrauterine development in these flies. The experiments were conducted in an experimental room (lux = 100) in two independent experiments: I.
View Article and Find Full Text PDFVision (Basel)
November 2024
Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy.
Dry eye disease (DED) has become increasingly prevalent in the digital era, largely due to prolonged screen exposure. The excessive use of digital devices contributes to inappropriate blink frequency and dynamics, leading to ocular surface dryness and discomfort. Additionally, digital screen use has broader implications for systemic health, including visual strain, headaches, and disrupted circadian rhythms caused by blue light exposure.
View Article and Find Full Text PDFMetabolites
December 2024
Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Circadian rhythms are intrinsic, 24 h cycles that regulate key physiological, mental, and behavioral processes, including sleep-wake cycles, hormone secretion, and metabolism. These rhythms are controlled by the brain's suprachiasmatic nucleus, which synchronizes with environmental signals, such as light and temperature, and consequently maintains alignment with the day-night cycle. Molecular feedback loops, driven by core circadian "clock genes", such as Clock, Bmal1, Per, and Cry, are essential for rhythmic gene expression; disruptions in these feedback loops are associated with various health issues.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
Department of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China.
Unlabelled: remains a non-negligible global zoonosis, imposing serious socio-economic burdens in endemic regions. The interplay between gut microbiota and the host transcriptome is crucial for maintaining health; however, the impact of juvenile infection on these factors is still poorly understood. This study aimed to investigate their relationship and potential pathogenic mechanisms.
View Article and Find Full Text PDFPhotochem Photobiol
December 2024
Graduate School of Informatics, Nagoya University, Nagoya, Japan.
Circadian clocks facilitate organisms' adaptation to the day-night environmental cycle. Some of the component genes of the clocks ("clock genes") respond directly to changes in ambient light, supposedly allowing the clocks to synchronize to and/or oscillate robustly in the environmental cycle. In the dicotyledonous model plant Arabidopsis thaliana, the clock genes CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), LATE ELONGATED HYPOCOTYL (LHY) and PSEUDO-RESPONSE REGULATOR 9 (PRR9) show transient expression in response to the morning light.
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