AI Article Synopsis
- The study analyzed the epidemiology and long-term survival outcomes of gastroenteropancreatic signet ring cell carcinoma (SRC) using data from the SEER database between 2000 and 2014.
- It found a slight decrease in the age-adjusted incidence of SRC over time, with stomach cancers exhibiting the highest rates, while improvements in overall survival were noted, particularly in early-stage and well-differentiated cases.
- The research concluded that SRC is associated with poor prognosis, primarily due to high tumor stages and differentiation at the time of diagnosis, indicating a need for better early detection and treatment strategies.
Article Abstract
Background: The epidemiology and clinical outcome of gastroenteropancreatic signet ring cell carcinoma (SRC) were not well illustrated. We aimed to explore the long-term epidemiology and predictors affect the overall survival (OS) of patients with SRC in gastrointestinal tract and pancreas.
Methods: Annual age-adjusted incidence, OS and survival trend of patients with gastroenteropancreatic SRC were evaluated in the Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2014. Multivariate Cox hazards regression model were used to identify predictive factors of the entity disease.
Results: Of the 24,613 patients in the cohort, 54.0% (13,295) were male gender. The age-adjusted incidence of SRC from January 2000 to December 2014 was decreased slightly. This trend appeared across all stages, grades and all the tumor locations, excerpt for esophagus and appendix. In regard to the incidence of SRC in gastrointestinal tract and pancreas, the stomach carried a higher incidence than other sites. Different primary site, stage and grade, and age of clinical diagnosis as well as time period of diagnosis were all found to have the significant median OS by multivariable analysis. Five years' OS of gastroenteropancreatic SRC was improving gradually between 2000-2014. In subgroups stratified by tumor stages and grades, the most pronounced improvement of survival over the same interval was observed in the early-stage and well differentiation SRC.
Conclusions: SRC in a heterogeneous US population tended to carry the poor prognosis with a high proportion of distant metastasis. The poor prognosis of SRC was mainly caused by high tumor stages and poor differentiation at diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776820 | PMC |
| http://dx.doi.org/10.21037/jgo.2019.06.07 | DOI Listing |
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