AI Article Synopsis
- Hepatitis B virus infection is linked to liver diseases and liver tumors, and this study examines the relationship between Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC).
- The research utilized the GSE14520 dataset for diagnostic and prognostic analysis, created a nomogram to estimate survival rates for HCC, and conducted gene set enrichment analysis.
- Findings indicate that HLA complex could serve as a diagnostic biomarker, with specific elements showing significant prognostic value for overall and recurrence-free survival in HCC patients.
Article Abstract
: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). : We used the GSE14520 dataset to explore diagnostic and prognostic significance between HLA complex and HCC. A nomogram was constructed to predict survival probability of HCC prognosis. Gene set enrichment analysis was explored using gene ontologies and metabolic pathways. Validation of prognostic values of the HLA complex was performed in the Kaplan-Meier Plotter website. : We found that showed the diagnostic value ( <0.0001, area under curve: 0.784, sensitivity: 93.14%, specificity: 62.26%). In addition, and showed prognostic values for overall survival, and and showed prognostic values for recurrence-free survival (all ≤ 0.05, elevated 0.927, 0.992, 1.023, 0.918, 0.937 multiples compared to non-tumor tissues, respectively). Gene set enrichment analysis found that they were involved in antigen processing and toll like receptor signalling pathway, etc. The nomogram was evaluated for survival probability of HCC prognosis. Validation analysis indicated that and - were associated with HCC prognosis of overall survival (all ≤ 0.05, elevated 0.988 and 0.997 multiples compared to non-tumor tissues, respectively). : might be a diagnostic and prognostic biomarker for HCC. and might be prognostic biomarkers for HCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775598 | PMC |
| http://dx.doi.org/10.7150/jca.29655 | DOI Listing |
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