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Efficacy and safety of guanfacine in hospitalized patients with delirium: A scoping review.
Crit Care Resusc
December 2024
Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia.
Objective: To assess current evidence regarding guanfacine use in hospitalized patients with delirium.
Introduction: Delirium is a common and important complication of critical illness. Central alpha-2 agonists are often used for symptomatic management.
The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification.
Biomolecules
December 2024
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
HIF-1α plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, the stability of HIF-1α increases, avoiding PHD and VHL protein-mediated degradation, which promotes its accumulation in cells and then activates gene expressions related to calcification. Additionally, HIF-1α modulates the metabolic state of VSMCs by regulating the pathways that govern the switch between glycolysis and oxidative phosphorylation, thereby further advancing the calcification process.
View Article and Find Full Text PDFProperties of New Partially Crystallized Lithium Disilicate CAD-CAM Materials.
Oper Dent
January 2025
*Kraig S. Vandewalle, DDS, MS, Col (ret), USAF, DC, Air Force Consultant in Dental Research Advanced Education in General Dentistry Residency, AF Postgraduate Dental School, Joint Base San Antonio - Lackland, TX, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Objective: The purpose of this study was to compare the optical, mechanical, and biological properties of two new, inexpensive lithium disilicate (LS2) materials (Lodden (LOD), LD Medical Technology; and BeautyZir (BZ), BeautyZir Technology) to a clinically established LS2 material (IPS e.max CAD (EMAX), Ivoclar Vivadent).
Methods And Materials: The optical properties of the translucency parameter (TP) and opalescence parameter (OP) were obtained with a dental spectrophotometer.
External validation of Prediabetes Risk Test in Indian population for screening prediabetes.
Med J Armed Forces India
December 2024
Professor & Unit Head (Medicine), Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Prediabetes Risk Test (PRT) has been found valid in the Western population for screening prediabetes. However, ethnicity, race, geographical and other biological characteristics have been linked to the development of prediabetes. There is a dearth of literature on the external validity of PRT in the Indian population.
View Article and Find Full Text PDFIDyOMpy: A new Python-based model for statistical analysis of musical expectations.
J Neurosci Methods
December 2024
Laboratoire des Systèmes Perceptifs, Département d'Étude Cognitive, École Normale Supérieure, PSL, Paris, France; Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, USA.
Background: IDyOM (Information Dynamics of Music) is the statistical model of music the most used in the community of neuroscience of music. It has been shown to allow for significant correlations with EEG (Marion, 2021), ECoG (Di Liberto, 2020) and fMRI (Cheung, 2019) recordings of human music listening. The language used for IDyOM -Lisp- is not very familiar to the neuroscience community and makes this model hard to use and more importantly to modify.
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