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The aim of this study was to evaluate the efficacy of Lu-prostate-specific membrane antigen (PSMA)-617 (Lu-PSMA) and selective internal radiation therapy (SIRT) for the treatment of liver metastases of castration-resistant prostate cancer. Safety and survival of patients with metastatic castration-resistant prostate cancer and liver metastases assigned to Lu-PSMA alone ( = 31) or in combination with SIRT ( = 5) were retrospectively analyzed. Additionally, a subgroup ( = 10) was analyzed using morphologic and molecular response criteria. Median estimated survival was 5.7 mo for Lu-PSMA alone and 8.4 mo for combined sequential Lu-PSMA and SIRT. Lu-PSMA achieved discordant therapy responses with both regressive and progressive liver metastases in the same patient (best vs. worst responding metastases per patient: -35% vs. +63% diameter change; < 0.05). SIRT was superior to Lu-PSMA for the treatment of liver metastases (0% vs. 56% progression). The combination of Lu-PSMA and SIRT is efficient and feasible for the treatment of advanced prostate cancer. Lu-PSMA alone seems to have limited response rates in the treatment of liver metastases.
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http://dx.doi.org/10.2967/jnumed.119.233429 | DOI Listing |
Br J Radiol
December 2024
Department of Radiology, Northern Jiangsu People's Hospital, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Objectives: To investigate the feasibility of radiomics models for predicting the source of hepatic metastases from gastrointestinal (GI) vs. non-gastrointestinal (non-GI) primary tumors on contrast enhanced CT(CECT).
Methods: 347 patients with liver metastases (180 from GI and 167 from non-GI) and abdominal CECT including arterial, portal venous, and delayed phases were divided into training (221) and validation (96) sets at a ratio of 7:3 and an independent testing set (30).
Expert Rev Anticancer Ther
December 2024
The Queen Elizabeth Hospital, Woodville, SA, AUS.
Introduction: Resection of primary tumor and liver metastases is the gold standard for colorectal cancer with liver-only metastases (CRLM). Although treatment options have expanded to enable conversion of unresectable to resectable CRLM, about 40% of patients will have definitively unresectable disease. Major advances in surgical techniques, immunosuppressive protocols and patient selection criteria for liver transplantation have resulted in improved outcomes.
View Article and Find Full Text PDFJ Blood Med
December 2024
Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Gallbladder adenocarcinoma has a high mortality rate, with approximately 1.7% cancer-related deaths worldwide. Cancer-associated thrombosis (CAT), including deep vein thrombosis (DVT), can significantly increase the risk of mortality within cancer patients, especially in pancreatic, brain, and intra-abdominal cancers, as well as in advanced and metastatic cancers.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, 100044, China.
Liver metastasis is the primary factor contributing to unfavorable prognosis in colorectal cancer (CRC). Although N-glycosylation is implicated in metastasis, there is a notable paucity of comprehensive studies addressing the N-glycosylation proteomics associated with liver metastasis in CRC. In this study, N-glycosylated proteins and N-glycosylation sites of differential expression between primary lesions and paired liver metastatic lesions are identified.
View Article and Find Full Text PDFSurg Endosc
December 2024
Department of General Surgery, Peking University Third Hospital, Beijing, 100191, China.
Background: Colorectal cancer (CRC) frequently metastasizes to the liver, significantly worsening patient outcomes. While hepatectomy offers the best curative option for colorectal liver metastases (CRLM), margin recurrence remains a major challenge post-surgery. Intraoperative ultrasound (IOUS) aids tumor identification and margin determination, but its limitations in laparoscopic surgery necessitate additional methods.
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