AI Article Synopsis
- A study of 4,148 hospitalized children with community-acquired pneumonia (CAP) revealed that 38.18% of those with Mycoplasma pneumoniae (Mp) were also co-detected with other pathogens, notably more in younger children (≤3 years).
- Most clinical symptoms and disease severity showed no significant differences between children with Mp alone and those with co-detection, although some specific symptoms like prolonged fever and runny nose were more common in those with Mp-viral co-detection.
- Findings indicate that while Mp co-detections with other pathogens are frequent, they generally do not alter the clinical presentation or severity of the illness.
Article Abstract
Background: Increasing number of hospitalized children with community acquired pneumonia (CAP) is co-detected with Mycoplasma pneumoniae (Mp). The clinical characteristics and impact of Mp co-detected with other bacterial and/or viral pathogens remain poorly understood. The purpose of this study was to evaluate the demographic and clinical features of CAP children with Mp mono-detection and Mp co-detection.
Methods: A total of 4148 hospitalized children with CAP were recruited from January to December 2017 at the Children's Hospital of Hebei Province, affiliated to Hebei Medical University. A variety of respiratory viruses, bacteria and Mp were detected using multiple modalities. The demographic and clinical features of CAP children with Mp mono-detection and Mp co-detection were recorded and analyzed.
Results: Among the 110 CAP children with Mp positive, 42 (38.18%) of them were co-detected with at least one other pathogen. Co-detection was more common among children aged ≤3 years. No significant differences were found in most clinical symptoms, complications, underlying conditions and disease severity parameters among various etiological groups, with the following exceptions. First, prolonged duration of fever, lack of appetite and runny nose were more prevalent among CAP children with Mp-virus co-detection. Second, Mp-virus (excluding HRV) co-detected patients were more likely to present with prolonged duration of fever. Third, patients co-detected with Mp-bacteria were more likely to have abnormal blood gases. Additionally, CAP children with Mp-HRV co-detection were significantly more likely to report severe runny nose compared to those with Mp mono-detection.
Conclusion: Mp co-detection with viral and/or bacterial pathogens is common in clinical practice. However, there are no apparent differences between Mp mono-detection and Mp co-detections in terms of clinical features and disease severity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788033 | PMC |
| http://dx.doi.org/10.1186/s12879-019-4426-0 | DOI Listing |
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