Background: Numerous studies have revealed the abnormal static functional connectivity (FC) among different brain regions in patients with generalized anxiety disorder (GAD). However, little is known about the dynamic changes of FC in patients with GAD.
Methods: This study investigated the whole-brain dynamic changes of FC in patients with GAD by combining global FC density (FCD) and sliding window correlation analyses. The standard deviation of dynamic FCD (dFCD) was calculated to evaluate its temporal variability along time. Support vector regression was then employed to predict the symptom severity of patients based on abnormal dynamic connectivity patterns.
Results: The abnormal dFCD variability between 81 GAD patients and 80 healthy controls showed that the patients had higher dFCD variability in the bilateral dorsomedial prefrontal cortex (dmPFC) and left hippocampus while lower dFCD variability in the right postcentral gyrus. The abnormal dFCD variability of the left dmPFC is an important feature for anxiety prediction.
Limitations: The selection of sliding window length remains controversial, and most of our patients have been treated with medications. Future studies are expected to rule out the potential confounding effects from applying different parameters of the sliding window and recruiting large samples of medication-free patients.
Conclusion: The altered patterns of time-varying brain connectivity in the frontolimbic and sensorimotor areas may reflect abnormal dynamic neural communication between these regions and other regions of the brain, which may deepen our understanding of the disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2019.09.084 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alternations voxel-wise interhemispheric and intrahemipheric functional connectivity dynamics in internet gaming disorder.
J Affect Disord
January 2025
Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, China. Electronic address:
Article Synopsis
- This study focuses on individuals with internet gaming disorder (IGDs) and their brain connectivity patterns, specifically examining how their brain regions connect functionally both at rest and over time.
- It compares 55 IGDs to 50 healthy controls (HCs) using resting-state functional MRI to evaluate differences in brain connectivity density (FCD) and temporal variability.
- The findings reveal that IGDs show decreased dynamic functional connectivity in key areas associated with visual attention, which correlates with the severity of their gaming issues, highlighting a potential neurobiological foundation for difficulties in concentration among these individuals.
Abnormal dynamics of functional connectivity density and effective connectivity in overactive bladder.
Neurourol Urodyn
November 2024
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Purpose: The study aims to analyze alterations in dynamic functional connectivity density (dFCD) and effective connectivity (dEC) patterns using functional magnetic resonance imaging (fMRI), hypothesizing that overactive bladder (OAB) patients will exhibit distinct dFCD and dEC patterns, reflecting altered neural communication underlying the OAB.
Methods: Forty-three female OAB patients and 40 female healthy controls (HC) underwent resting-state fMRI. Sliding window correlation was used to calculate the variability of the dFCD.
Abnormal Dynamics of Functional Connectivity Density Associated With Chronic Neck Pain.
Front Mol Neurosci
June 2022
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
: Chronic neck pain (CNP) is highly prevalent and complicated, associated with limited movement, and accompanied by shoulder pain and other clinical manifestations such as dizziness, anxiety, and insomnia. Brain structural and functional abnormalities often occur in patients with CNP. However, knowledge of the brain's functional organization and temporal dynamics in CNP patients is limited.
View Article and Find Full Text PDFAbnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug-naïve first-episode schizophrenia patients with auditory verbal hallucinations.
Hum Brain Mapp
October 2022
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Numerous studies indicate altered static local and long-range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics of interhemispheric and intrahemispheric functional connectivity patterns remain unknown in schizophrenia patients with AVHs. We analyzed resting-state functional magnetic resonance imaging data for drug-naïve first-episode schizophrenia patients, 50 with AVHs and 50 without AVH (NAVH), and 50 age- and sex-matched healthy controls.
View Article and Find Full Text PDFMore Than Just Statics: Temporal Dynamic Changes in Inter- and Intrahemispheric Functional Connectivity in First-Episode, Drug-Naive Patients With Major Depressive Disorder.
Front Hum Neurosci
April 2022
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Several functional magnetic resonance imaging (fMRI) studies have demonstrated abnormalities in static intra- and interhemispheric functional connectivity among diverse brain regions in patients with major depressive disorder (MDD). However, the dynamic changes in intra- and interhemispheric functional connectivity patterns in patients with MDD remain unclear. Fifty-eight first-episode, drug-naive patients with MDD and 48 age-, sex-, and education level-matched healthy controls (HCs) underwent resting-state fMRI.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!