AI Article Synopsis
- Behcet's disease (BD) is a type of vasculitis, and this study examines the potential of specific miRNAs (miR-21, miR-146b, and miR-326) as diagnostic and prognostic markers for the disease.
- The study involved 46 BD patients and 70 healthy volunteers, using quantitative real-time PCR to measure miRNA expression levels.
- Findings showed that BD patients had lower levels of miR-21 and miR-146b, but higher levels of miR-326, with the latter being particularly useful in predicting severe eye involvement and uveitis in these patients.
Article Abstract
Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.
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| http://dx.doi.org/10.2217/bmm-2019-0098 | DOI Listing |
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