Background: The aim of this study includes synthesis of zinc dimethacrylate ionomer (ZDMA) by a new method, incorporate it into resin bonding and evaluate its antibacterial, physical and mechanical properties.
Material And Methods: Resin adhesives containing 0 to 5% wt of ZDMA was produced and the following tests were accomplished: A: Antibacterial test: 1.Direct contact test. 2.Material aging; in both of them the bacterial colony counting were performed. B: Physical test: 1.Degree of conversion (D.C). 2.Evaluating the amount of released Zinc ion release in aqueous medium. C: Mechanical test: 1.Compressive strength test. 2.Shear bond test (enamel and dentine separately). The obtained results were statistically analyzed using One Way ANOVA and LSD post hoc test (α=0.05).
Results: The anti-bacterial test revealed that all the ZDMA containing groups significantly reduced the amount of Streptococcus Mutans bacteria. Moreover, the D.C in all ZDMA groups was enhanced. Furthermore, ion release analysis revealed noticeable stability of Zn2+ in samples, as in the 5wt.% group it was even after nine cycle of 24h wash. On the other hand, the compressive strength was significantly reduced just in the 5% ZDMA group while the other groups were superior comparing to the control. In addition, there was no significant difference among the enamel shear bond strength of the groups. However, about the dentine shear bond strength, only the 5% ZDMA group was significantly higher than the control.
Conclusions: Low percentages of ZDMA in adhesive could impart anti-bacterial efficacy without challenging its mechanical and physical properties. Dental Resin Bonding, Zinc, Streptococcus mutans, Degree of conversion, Compressive strength.
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http://dx.doi.org/10.4317/jced.55636 | DOI Listing |
Mar Drugs
January 2025
Institute for Bioengineering, The School of Engineering, The University of Edinburgh, Edinburgh EH9 3DW, UK.
Fucoidan is a sulfated polysaccharide found in brown seaweed. Due to its reported biological activities, including antiviral, antibacterial and anti-inflammatory activities, it has garnered significant attention for potential biomedical applications. However, the direct relationship between fucoidan extracts' chemical structures and bioactivities is unclear, making it extremely challenging to predict whether an extract will possess a given bioactivity.
View Article and Find Full Text PDFGels
January 2025
Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1983963113, Iran.
The skin serves as a critical barrier against external pathogens, and its wound healing is a complex biological process that requires careful management to ensure optimal tissue regeneration. Hydrogels, a class of hydrophilic polymers, have emerged as promising materials for wound dressings due to their biocompatibility, biodegradability, and ability to create a moist wound environment conducive to cell proliferation and migration. In this research, a hydrogel dressing containing cefdinir (Cef) was made from a combination of carboxymethyl cellulose (CMC) and gelatin (Gel) by a physical crosslinking method, and their physicochemical, mechanical, and biological properties were investigated.
View Article and Find Full Text PDFGels
January 2025
Institute of Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Researchers have been investigating the physical and morphological properties of biodegradable polymer and copolymer films, blending them with other chemicals to solve challenges in medical, industrial, and eco-environmental fields. The present study introduces a novel, straightforward method for preparing biodegradable hydrogels based on polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) for medical applications. The resulting PVA/PVP-based hydrogel uniquely combines the water absorbency, biocompatibility, and biodegradability of the polymer composite.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Department of Pharmaceutical Sciences, Shalom Institute of Health & Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, 211007, Uttar Pradesh, India.
Background: Thymoquinone (TQ) is found in the seeds of Nigella sativa. It has immunomodulatory, antibacterial, anti-inflammatory, antioxidant, astringent, antifungal, and antihistaminic properties, making it a highly valuable compound of interest. However, the use of it as a therapeutic drug is highly challenging because of its poor solubility, low bioavailability, and short-term stability.
View Article and Find Full Text PDFZhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2025
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, P. R. China.
Objective: To summarize the latest research progress of graphene and its derivatives (GDs) in bone repair.
Methods: The relevant research literature at home and abroad in recent years was extensively accessed. The properties of GDs in bone repair materials, including mechanical properties, electrical conductivity, and antibacterial properties, were systematically summarized, and the unique advantages of GDs in material preparation, functionalization, and application, as well as the contributions and challenges to bone tissue engineering, were discussed.
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