AI Article Synopsis
- * Glutaminase isoenzymes (GLS and GLS2) are important for glutamine metabolism, but they have opposite effects on cancer development.
- * The review discusses glutaminase's impact on breast cancer, the influence of oncogenes and tumor suppressor genes in its regulation, and explores potential therapeutic strategies targeting glutaminase.
Article Abstract
Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with different morphological and molecular subtypes and responses to therapy, and breast cancer cells are known to rewire glutamine metabolism to support survival and proliferation. Glutaminase isoenzymes (GLS and GLS2) are key enzymes for glutamine metabolism. Interestingly, GLS and GLS2 have contrasting functions in tumorigenesis. In this review, we explore the role of glutaminase in cancer, primarily focusing on breast cancer, address the role played by oncogenes and tumour suppressor genes in regulating glutaminase, and discuss current therapeutic approaches to targeting glutaminase.
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| http://dx.doi.org/10.1111/his.14014 | DOI Listing |
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